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IRCT2013122215891N1 IRCT 2014-06-20 Dr. Minaei; Vice chancellor for research Traditional Medicine Faculty of Tehran University of Medica hyperprolactinemia Comparative study of the effect of marticaria chamomilla syrup and cabergoline on hyperprolactinemia 2014-07-23 anticipated 158 Complete https://irct.ir/trial/15020 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Hyperprolactinaemia. Intervention 1: Medication administration ( marticaria chamomilla syrup) 5 cc two times a day for 4 weeks. Intervention 2: Cabergoline 0.25 mg twice a week.
public Marya Kabiri
Behesht Ave., Vahdat eslami St.
Tehran Iran (Islamic Republic of) 009821:55601274 m-kabiri@razi.tums.ac.ir, marya_kabiri@yahoo.om Traditional Medicine Faculty, Tehran University of Medical Sciences scientific Dr. Farnaz Sohrabvand
Emam Khomeini Hospital, Keshavar Boulevard
Tehran Iran (Islamic Republic of) +98 21 6119 2741 fsohrabvand@yahoo.com Tehran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Patient satisfaction; Female; Outpatients older than 18 years; Patient with asymptomatic or mild symptoms idiopathic hyperprolactinemia (menstrual disorders that are just starting with or without galactorrhea or without bothering galactorrhea alone); Serum prolactin level above 25 μgr/L Exclusion criteria: Patients older than 45 years; Patient with liver failure; Patient with kidney failure; Patient with hypothyroidism; Taking medication such as haloperidol, phenothiazine, butyrophenone, monoamine oxidase inhibitor, fluoxetine, sulpiride, metoclopramide, domperidone, tricyclic antidepressants, opioid, estrogen, verapamil, reserpine, methyldopa, benzodiazepine, cimetidine, medroxolol drugs and any medication that is effective in prolactin secretion in the last three months; The use of warfarin; The use of sedating; Prolactinoma( micro or macro adenoma); Adrenal, pituitary and hypothalamus disease; Pregnant women; Women who plan to become pregnant; Breast feeding; Autoimmune disease such as lupus; Long- term menstural disorders; Bothering galactorrhea; Underlying disease such as diabetes, hypertension and cancer; History of hyperprolactinemia treatment in the last 6 months; The use of propranolol and vasoconstrictor drugs; Raynaud’s disease; History sensitivity to ergot derivatives; History of stomach ulcers and gastrointestinal bleeding; Asthma; History of hay fever and allergic reaction to member of the compositae family such as yarrow, feverfew, artemisia, tansy 18 years 45 years Female E 22.1 Hyperprolactinaemia Treatment - Drugs Treatment - Drugs Medication administration ( marticaria chamomilla syrup) 5 cc two times a day for 4 weeks. Cabergoline 0.25 mg twice a week Serum prolactin level. Timepoint: Before and after the intervention. Method of measurement: Laboratory measurement. Side effects. Timepoint: During the treatment. Method of measurement: questionnaire and Physical exam. Dr. Minaei; Vice chancellor for research Traditional Medicine Faculty of Tehran University of Medica Approved 2014-04-09 Ethics Committee, Faculty of Traditional Medicine, Tehran University of Medical Sciences Keshavarz Blv Ghods St Tehran Tehran Iran (Islamic Republic of)