IRCT2013122815841N1 IRCT 2014-01-16 Research Council of Tehran University of Medical Sciences comparison the effect of hypertonic saline and sodium bicarbonate on early graft function in kidney transplantation NGAL: neutrophil Gelatinase-associated Lipocalin. IL-10;interleukin 10 DGF:delay graft func Effect of hypertonic saline 5% and sodium bicarbonate 8.4% on early graft function and the urinary levels of IL-18 and Neutrophil Gelatinase-associated Lipocalin (NGAL) as biomarkers of acute kidney injury in patients receiving kidney transplants from deceased donors 2013-09-23 anticipated 60 Complete https://irct.ir/trial/14987 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A kidney transplantation. Intervention 1: hypertonic saline group: 4ml/kg hypertonic saline 5% is administered before declamping during kidney transplant procedure. Intervention 2: control group; 60 ml/kg normal saline solution administered during kidney transplant procedure to maintain CVP between 8 and 15 cm H2O. Intervention 3: sodium bicarbonate group: during kidney transplant procedure pH is controlled tightly based on BD values by administration of sodium bicarbonate 8.4% and BE maintained above -5 m mol/L.