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IRCT2013121415780N1 IRCT 2014-03-15 Drug Applied Research Center, Tabriz University of Medical Sciences Ginger effect on chemotherapy-induced neuropathy Assessment of ginger and corn starch effect on chemotherapy-induced neuropathy in patients with ovarian and lung cancer 2014-01-20 anticipated 52 Complete https://irct.ir/trial/14940 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive. 2 Condition 1: ovarian cancer. Condition 2: lung cancer. Intervention 1: Supplemented group: 2 g oral ginger daily( 2 one-gram tablets of ginger)for 18 weeks. Intervention 2: Placebo group: 2 g oral corn starch daily( 2 one-gram tablets of corn starch)for 18 weeks.
public Zohreh Ghoreishi
Nutrition Research Center, Faculty of Health & Nutrition, Attar St., Tabriz, Iran
Tabriz Iran (Islamic Republic of) +98 41 1335 2295 ghoreishiz@tbzmed.ac.irzohreh_ghoreishy@yahoo.com Nutrition Research Center, Tabriz University of Medical Sciences scientific Zohreh Ghoreishi
Nutrition Research Center, Faculty of Health & Nutrition, Attar St., Tabriz, Iran
Tabriz Iran (Islamic Republic of) +98 41 1335 2295 ghoreishiz@tbzmed.ac.ir Nutrition Research Center, Tabriz University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion Criteria:suffering from ovarian cancer; non-small cell lung cancer; willingness to corporate. Exclusion Criteria:age more than 70 years; suffering from diabetes; AIDS;hyperthyroidism; primary neurological diseases; other kinds of malignancies; history of chemotherapy; consumption of vitamin; mineral or fish oil supplementation at list 3 months before the enrollment; Ginger sensitivity 18 years 70 years Both C56 C34 Malignant neoplasm of ovary Malignant neoplasm of bronchus and lung Prevention Prevention Supplemented group: 2 g oral ginger daily( 2 one-gram tablets of ginger)for 18 weeks Placebo group: 2 g oral corn starch daily( 2 one-gram tablets of corn starch)for 18 weeks Incidence of chemotherapy-induced peripheral neuropathy. Timepoint: before the onset of chemotherapy and after 18 weeks, at the end of the treatment period. Method of measurement: rTNS Score, Nerve Conduction Studiy. Severity of chemotherapy-induced peripheral neuropathy. Timepoint: before the onset of chemotherapy and after 18 weeks, at the end of the treatment period. Method of measurement: rTNS Score, Nerve Conduction Studiy. Serum levels of pro-inflammatory cytokines. Timepoint: before the onset of chemotherapy and after 18 weeks at the end of treatment. Method of measurement: ELISA. Total Antioxidant Status (TAS). Timepoint: before the onset of chemotherapy and after 18 weeks at the end of treatment. Method of measurement: Spectrophotometry. Serum level of MDA. Timepoint: before the onset of chemotherapy and after 18 weeks at the end of treatment. Method of measurement: Spectrophotometry. Activity of SOD & GPX enzymes in RBC. Timepoint: before the onset of chemotherapy and after 18 weeks at the end of treatment. Method of measurement: Spectrophotometry. Nutrition Research Center, Tabriz University of Medical Sciences Physical Medicine & Rehabilitation Research Center, Tabriz University of Medical Sciences Hematology and Oncology Research Center, Tabriz University of Medical Sciences Drug Applied Research Center, Tabriz University of Medical Sciences Nutrition Research Center, Tabriz University of Medical Sciences Physical Medicine & Rehabilitation Research Center, Tabriz University of Medical Sciences Hematology and Oncology Research Center, Tabriz University of Medical Sciences Approved 2014-01-20 Tabriz University of Medical Sciences Tabriz University of Medical Sciences, Daneshgah St., Tabriz, Iran Tabriz Iran (Islamic Republic of)