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IRCT2015120415634N2 IRCT 2017-09-27 Imam Hossein Hospital ; Preventive Gynecology Research Center The effect ofantenatal intramuscular adminestration of two doses of betamethasone every 12 hours on acute pulmonary complications in preterm infants born Comparing of antenatal intramuscular adminestration of two doses of betamethasone every 12 hours with standard method every 24 hours on acute neonatal pulmonary complications in preterm infants born from women with preterm premature of membrane 2012-03-20 anticipated 156 Complete https://irct.ir/trial/14842 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: randomization by table of random number. N/A Respiratory and cardiovascular disorders specific to the perinatal period. Intervention 1: Caspian tamin,Pharmaceutical Co.Rhast-IRAN,Betamethasone 4mg/ml .( In control group : Antenatal intramuscular two doses of 12 mg betamethasone every 24 hours administer to women with preterm premature of membrane) . Intervention 2: Caspian tamin,Pharmaceutical Co.Rhast-IRAN,Betamethasone 4mg/ml . ( In intervention group : Antenatal intramuscular two doses of 12 mg betamethasone every 12 hours administer to women with preterm premature of membrane) .
public Parisa Hashemi
FADAIAN ISLAM HIGH WAY ,SHOOSH SQUARE
Tehran Iran (Islamic Republic of) +98 21 5506 6263 parisahashemi62@yahoo.com Mahdiyeh Hospital scientific tayebeh Jahed Bozorgan
Mahdiyeh Hospital
Tehran Iran (Islamic Republic of) +98 21 5506 6263 tayebeh.jahed@yahoo.com;tayebe.jahed@sbmu.ac.ir Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: " Healthy women pregnant with singleton pregnancies and premature rupture of membranes at gestational age 26 to 34 weeks without the need for an immediate termination of pregnancy" . Exclusion criteria:" Presence of any increased blood pressure; diabetes ; chorioamnionitis ; intrauterine growth retardation; fetal anomaly; fetal distress ; steroid use by mother and any disease that corticosteroids use are contraindicated'. no limit no limit Female Respirator Hyaline membrane disease Treatment - Drugs Treatment - Drugs Caspian tamin,Pharmaceutical Co.Rhast-IRAN,Betamethasone 4mg/ml .( In control group : Antenatal intramuscular two doses of 12 mg betamethasone every 24 hours administer to women with preterm premature of membrane) . Caspian tamin,Pharmaceutical Co.Rhast-IRAN,Betamethasone 4mg/ml . ( In intervention group : Antenatal intramuscular two doses of 12 mg betamethasone every 12 hours administer to women with preterm premature of membrane) . Occurrence of Respiratory distress of newborn. Timepoint: First seven days of the neonatal period. Method of measurement: questionnaire. APGAR. Timepoint: The first and fifth minutes after birth. Method of measurement: questionnaire. Imam Hossein Hospital ; Preventive Gynecology Research Center Approved 2014-09-28 Ethics committee of the Shahid Behesti University of the Medical Sciences ,Theran , Iran " SIDE OF AYATOLLAH TALEGANI HOSPITAL , SHAHID ARABI AVENUE , YAMAN AVENUE ,SHAHID CHAMRAN HIGHWAY " Tehran Iran (Islamic Republic of)