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IRCT2017081215510N3 IRCT 2017-09-24 Technology Assistant, Mazandaran University Of Medical Sciences Comparing the Efficacy of14 days Reverse Hybrid Regimen and 14 days concomitant Therapy for HP eradication Comparing the Efficacy of14 days Reverse Hybrid Regimen and 14 days concomitant Therapy for HP eradication 2017-05-22 anticipated 260 Complete https://irct.ir/trial/14761 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Gastric Ucer. Intervention 1: In intervention group (reverse hybrid group): patients in the first 7 days of treatment receive pantoprazole 40 mg, amoxicillin 1g, clarithromycin 500 mg, metronidazole 500 mg every 12 hours, and the second 7 days, clarithromycin and metronidazole were interrupted and only Pentoprazole and amoxicillin are continued at the same dose. Intervention 2: In control group: (14 days concomitant group): four drugs: pantoprazole 40 mg, amoxicillin 1g, clarithromycin 500 mg and metronidazole 500 mg every 12 hours for 14 days prescribed.
public Seyed Mohammad Valizadeh Toosi
Imam Khomeni Hospital
Sari Iran (Islamic Republic of) 481666-33131 +98 11 3337 7176 gutliver@yahoo.com Gut and Liver research Center, Mazandaran University Of Medical Sciences scientific Seyed Mohammad Valizadeh Toosi
Imam Khomeni Hospital
Sari Iran (Islamic Republic of) 481666-33131 +98 11 3337 7176 sm.valizadehtoosi@mazums.ac.ir; seyedmohammadv@yahoo.com Gut and Liver research Center, Mazandaran University Of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Patients with endoscopic findings of gastric or duodenal ulcer or gastric and duodenal erosoin and have Helicobacter pylori infection ; patients older than 18 year and less than 80 years. Exclusion criteria : pregnancy and lactation ; previously received Helicobacter pylori therapy ; patients received PPI (poroton poup inhibitor) or H2 RA (histamine 2 receptor antagonist) in last 2 weeks or within 4 weeks who received antibiotics ; history of surgery on the stomach ; Patients with confirmed advanced disease , severe cardiac, pulmonary , endocrine , chronic renal failure, chronic liver disease or have cancer ; The consumption of alcoholic beverages 18 years 80 years Both K25 gastric ulcer Treatment - Drugs Treatment - Drugs In intervention group (reverse hybrid group): patients in the first 7 days of treatment receive pantoprazole 40 mg, amoxicillin 1g, clarithromycin 500 mg, metronidazole 500 mg every 12 hours, and the second 7 days, clarithromycin and metronidazole were interrupted and only Pentoprazole and amoxicillin are continued at the same dose. In control group: (14 days concomitant group): four drugs: pantoprazole 40 mg, amoxicillin 1g, clarithromycin 500 mg and metronidazole 500 mg every 12 hours for 14 days prescribed. Helicobacter pylori infection. Timepoint: Before intervention and 12 weeks after intervention. Method of measurement: Upper GI endoscopy and biopsy for pathology and RUT for HP infection before intervention and endoscopy and biopsy or urea breath test and or stool examination for HP antigen for HP infection after intervention. HP eradication rate and drug adverse effects and patients compliance in two groups. Timepoint: 12 weeks after initiation of therapautic regimens. Method of measurement: Urea breath test, stool exam for HP antigen and or endoscopy and biopsy. questionary assesment. Technology Assistant, Mazandaran University Of Medical Sciences Approved 2017-11-22 Technology deputy, Mazandaran University Of Medical Sciences Moallem Squre Sari Iran (Islamic Republic of)