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IRCT2015022215446N2 IRCT 2015-10-07 Vice challencor for reasearch of Ahvaz Jundishapur University of Medical Sciences Effect of infusion of B-type Natriuretic Peptide in Acute Exacerbation of Asthma Bronchodilator Effect of B-Type Natriuretic Peptide in Acute Asthma Attack Patients (Randomized Controlled Trial Phase I & II) 2015-05-22 anticipated 40 Complete https://irct.ir/trial/14707 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Method of closed envelopes that randomely puts the patient in one of intervention or control groups will be used. 1-2 Acute Exacerbation of Asthma. Intervention 1: Intervention Group: Salbutamol 2.5mg each 20 minutes via nebulizer Atrovent 2.5mg each 20 minutes via nebulizer Prednisolone 50mg one time by mouth MgSO4 2gr one time IV infusion in 20 minutes BNP 2mcg per kilogram IV Bolus BNP 0.01mcg per kilogram IV Infusion in first 30 minutes BNP 0.02mcg per kilogram IV Infusion in second 30 minutes BNP 0.03mcg per kilogram IV Infusion in third 30 minutes. Intervention 2: Control Group: Salbutamol 2.5mg each 20 minutes with nebulizer Atrovent 2.5mg each 20 minutes with nebulizer Prednisolone 50mg by mouth one time MgSO4 2g intravenous infusion in 20 minutes.
public Dr Hassan Motamed
Golestaan hospital, Golestan st.
Ahvaz Iran (Islamic Republic of) +98 61 3374 3079 motamed-h@ajums.ac.ir Ahvaz University of Medical Sciences scientific Dr. Hassan Motamed
Golestaan hospital, Golestan st.
Ahvaz Iran (Islamic Republic of) +98 61 3374 3079 motamed-h@ajums.ac.ir Ahvaz Jundishapur University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion Criteria: Acute Asthma Attack with: Age above 18 years old; Clinically or Para-clinically Asthma History Exclusion Criteria: History of Cardiovascular Diseases; History of COPD; History of other pulmonary diseases; History of Smoking more than 10 years; Pregnant women; History of hypersensitivity to the BNP; Systolic Blood Pressure less than 100 mmHg 18 years 80 years Both J45 Asthma Treatment - Drugs Treatment - Drugs Intervention Group: Salbutamol 2.5mg each 20 minutes via nebulizer Atrovent 2.5mg each 20 minutes via nebulizer Prednisolone 50mg one time by mouth MgSO4 2gr one time IV infusion in 20 minutes BNP 2mcg per kilogram IV Bolus BNP 0.01mcg per kilogram IV Infusion in first 30 minutes BNP 0.02mcg per kilogram IV Infusion in second 30 minutes BNP 0.03mcg per kilogram IV Infusion in third 30 minutes Control Group: Salbutamol 2.5mg each 20 minutes with nebulizer Atrovent 2.5mg each 20 minutes with nebulizer Prednisolone 50mg by mouth one time MgSO4 2g intravenous infusion in 20 minutes Forced Expiratory Volume in First Second (FEV1). Timepoint: Before intervention, 30 minutes after intervention, 60 minutes after intervention, 90 minutes after intervention. Method of measurement: Milliliter with use of Peak Flow Meter. Peak Expiratory Flow Rate (PEFR). Timepoint: Before intervention, 30 minutes after intervention, 60 minutes after intervention, 90 minutes after intervention. Method of measurement: Milliliter with use of Peak Flow Meter. Blood Pressure. Timepoint: Before Intervention. Method of measurement: Millimeter of Hg. Vice challencor for reasearch of Ahvaz Jundishapur University of Medical Sciences Approved 2015-04-29 Ethics Committee of Ahvaz University of Medical Sciences Research Assistant, Next to central Building, Ahvaz Jundishapur University of Medical Sciences, University town, Ahvaz Ahvaz Iran (Islamic Republic of)