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IRCT2013111015178N2 IRCT 2014-01-03 Mazandaran University of Medical Sciences therapeutic effects of Carvidelol and Metoprolol in prevention of cardiac arrhythmia after open heart surgery Comparing therapeutic effects of carvedilol and metoprolol in prevention of atrial fibrillation after coronary artery bypass surgery, double blinded study 2012-03-20 anticipated 150 Complete https://irct.ir/trial/14525 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. 3 Atrial fibrillation. Intervention 1: A total of 150 patients 75 in each drug group, enroll in the study.Initiative dose is going to be 25 mg/BD in metoprolol group and will increase according to the patients’ hemodynamic responses.Cardiac monitoring going to performe in patients during ICU and 5 days post-ICU. Intervention 2: A total of 150 patients 75 in each drug group, enroll in the study.Initiative dose is going to be 6.25 daily in carvideloll group and increase according to the patients’ hemodynamic responses.Cardiac monitoring is going to performe in patients during ICU and 5 days post-ICU.
public Rozita Jalalian
Mazandaran Heart Center, Artesh BLVD
Sari Iran (Islamic Republic of) +98 15 1222 4002 rozita_jalalian@yahoo.com Mazandaran University of Medical Sciences scientific Rozita Jalalian
Mazandaran Heart Center, Artesh BLVD
Sari Iran (Islamic Republic of) +98 15 1222 4002 rozita_jalalian@yahoo.com Mazandaran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: patients indicated for CABG surgery who did not have any contraindications for beta blocker use .Exclusion criteria: chronic obstructive respiratory failure; advanced AV block; previous AF; bradycardia (HR<60); hypotension (SBP<90); ejection fraction<35%; patients who were undergoing repair or replace of heart valve along with their CABG surgery. 21 years 81 years Both I48 Atrial fibrillation and flutter Prevention Prevention A total of 150 patients 75 in each drug group, enroll in the study.Initiative dose is going to be 25 mg/BD in metoprolol group and will increase according to the patients’ hemodynamic responses.Cardiac monitoring going to performe in patients during ICU and 5 days post-ICU A total of 150 patients 75 in each drug group, enroll in the study.Initiative dose is going to be 6.25 daily in carvideloll group and increase according to the patients’ hemodynamic responses.Cardiac monitoring is going to performe in patients during ICU and 5 days post-ICU Atrial fibrillation. Timepoint: During the first 5 days after CABG. Method of measurement: Cardiac monitoring. Ventricular fibrillation. Timepoint: During the first 5 days after CABG in ICU. Method of measurement: Cardiac monitoring. Mazandaran University of Medical Sciences Approved 2012-12-19 Mazandaran University of Medical Sciences Juybar Interaction Sari Iran (Islamic Republic of)