IRCT138802091859N1 IRCT 2013-02-07 Vice President, Science and Technology Branch Saffron in treatment of Multiple Sclerosis Evaluation of the saffron effect on improvement of physical and cognitive symptoms in patients with Multiple Sclerosis compared with the placebo 2013-01-20 anticipated 60 Complete https://irct.ir/trial/1448 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomization: Stratified Block randomization since some of the data which will be used to measure primary or secondary outcomes is gathered by physical examination, the study has been designed as a double-blind clinical trial. Knowing in which group the patient is may affect examiners’ clinical judgment. 2 Multiple Sclerosis. Intervention 1: Saffron tablet, chemical formulation the stigma of the Saffron plant, (500 milligram three times a day, oral) for 12 months, made in Drug Unit, School of Pharmacy in Tehran University of Medical Sciences in Islamic Republic Of Iran, not having generic name. Intervention 2: Placebo tablet, chemical formulation filling materials used in the preparation of pharmaceutical products (500 milligram three times a day, oral) for 12 months, made in Drug Unit, School of Pharmacy in Tehran University of Medical Sciences in Islamic Republic Of Iran.