IRCT20130921014727N7 IRCT 2021-09-23 Faculty of Pharmacy, Shahid Behesti University of Medical Sciences The Evaluation of Safety and Efficacy of Cyproheptadine in Pulmonary Arterial Hypertension The Pilot Study of Efficacy and Safety of Cyproheptadine in Pulmonary Arterial Hypertension Patients in Massih Daneshvari Hospital 2015-01-20 anticipated 12 Complete https://irct.ir/trial/14274 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: in this study we will use unrestricted or simple randomization. the study utilizes individual sampling. we are using a random number table to randomize patients. patients in our center are numbered and even numbers are allocated to the drug group and odd numbers are allocated to the placebo group. numbers on the table select from the top left corner and the direction is toward the bottom right corner. every patient will receive a can containing pills. each pill can is labeled with a specific number that indicates drug or placebo. the numbers' information will have been hidden from patients and researchers by the time of analysis, Blinding description: Each drug label has a number which indicates that the patient using the drug or the placebo. list of numbers are keeping hidden from patients and research team. 4 primary pulmonary hypertension. Intervention 1: for intervention group: cyproheptadine 4mg PO q12hr for 3 monthes. Intervention 2: for control group: identical placebo tablet q12hr PO for 3 monthes. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is we need to discuss and decide about reporting IPD