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IRCT2013092014717N1 IRCT 2015-05-13 Research Vice-Chancellor of Shiraz University of Medical Sciences The effect of Selenium and Vitamin C for treatment of Hashimoto thyroiditis Effect of treatment with Selenium and Vitamin C in comparison to placebo on serum level of anti-thyroid peroxidase antibody in patients with Hashimoto, thyroiditis, a clinical trial 2012-09-22 anticipated 84 Complete https://irct.ir/trial/14265 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Hashimoto thyroiditis. Intervention 1: The first intervention group will receive Selenium 200 micrograms tablet daily by mouth, for 3 to 6 months. Selenium tablets will be prepared from Sodium Selenate from Merck company by Shiraz school of pharmacy. The tablets will be similar to the tablets of the other two groups. Intervention 2: The second intervention group will receive 500 milligrams tablet of Vitamin C daily, by mouth, for 3 to 6 months. Vitamin C tablets will be prepared by Avicenna company. Intervention 3: The control group will receive one tablet of placebo which will contain starch and will be similar to the real drugs. The placebo tablets will be prepared by Shiraz school of pharmacy.
public Dr. Fariba Karimi
Department of Internal Medicine, Namazee Hospital, Namazee Square, Zand Street, Shiraz, Iran
Shiraz Iran (Islamic Republic of) 7193711351 +98 71 3647 4316 karimif@sums.ac.ir Shiraz University of Medical Sciences scientific Dr. Fariba Karimi
Department of Internal Medicine, Namazee Hospital, Namazee Square, Zand Street, Shiraz, Iran
Shiraz Iran (Islamic Republic of) 7193711351 +98 36246096 karimif@sums.ac.ir,karimif2002@yahoo.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: age, 15 years old or more; anti-thyroid peroxidase antibody titer 200 units per liter or more. Exclusion criteria: pregnant women; previous history of thyroid disorders; previous history of hypothalamo-hypophyseal disorders; presence of nonthyroidal disorders (such as renal; hepatic; cardiovascular disorders; diabetes mellitus; infectious diseases; renal stone; etc) ; consumption of drugs with effect on thyroid hormones metabolism; consumption of sex hormones; glucocorticoids; vitamins or supplements 15 years 80 years Both E06.3 Autoimmune thyroiditis Treatment - Drugs Treatment - Drugs Treatment - Drugs The first intervention group will receive Selenium 200 micrograms tablet daily by mouth, for 3 to 6 months. Selenium tablets will be prepared from Sodium Selenate from Merck company by Shiraz school of pharmacy. The tablets will be similar to the tablets of the other two groups The second intervention group will receive 500 milligrams tablet of Vitamin C daily, by mouth, for 3 to 6 months. Vitamin C tablets will be prepared by Avicenna company The control group will receive one tablet of placebo which will contain starch and will be similar to the real drugs. The placebo tablets will be prepared by Shiraz school of pharmacy Titer of anti-thyroid peroxidase antibody. Timepoint: Before and after 3 to 6 months of treatment. Method of measurement: Measurement of anti-thyroid peroxidase antibody titer in serum by radioimmunoassay method. Thyroid function test including: thyroxine, thriiodothyronine, and thyroid stimulating hormone levels. Timepoint: Before treatment and after completion of treatment course. Method of measurement: Measurement of serum levels of hormones by immunoradiometric assay method. Research Vice-Chancellor of Shiraz University of Medical Sciences Approved 2012-06-14 Shiraz University of Medical Sciences Department of Vice-Chancellor of Research of Shiraz University of Medical Sciences, 7th Floor, Central Building of Shiraz University of Medical Science, Zand Street, Shiraz, Iran Shiraz Iran (Islamic Republic of)