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IRCT2015101714333N43 IRCT 2015-10-30 Vice chancellor for research, Kermanshah University of Medical Sciences Effect of Allopurinol on Chronic Kidney Disease Progression. Effect of Allopurinol on progression of renal disease 2014-10-17 anticipated 180 Complete https://irct.ir/trial/13977 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Chronic renal failure. Intervention 1: In the experimental group allopurinol 100 mg will be given under the supervision of nephrologist ,daily for 12 months. Then at beginning of the study, and at 3,6 and 12 months the kidney function of patients with GFR, uric acid and creatinine is assessed. Intervention 2: In the control group will receive 100 mg of placebo daily for 12 months. Then at beginning of the study, and at 3,6 and 12 months the kidney function of patients with GFR, uric acid and creatinine is assessed.
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scientific Dr.Sima Golmohammadi
Emam Reza Hospital, Parastar Boulevard
Kermanshah Iran (Islamic Republic of) +98 83 3427 6309 simag_2000@yahoo.com Kermanshah University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: informed consent of the patient;the diagnosis of renal glomerular filtration ;(GFR) of less than 60 and over 15; uric acid greater than 6 mg per dL; age over 18 years; no history of hospitalization during the past three months due to renal disease and no increase in creatinine number greater than 50% compared to the 3months ago. Exclusion criteria: allopurinol intolerance;allergy; the possibility of pregnancy; liver disease history of gout 18 years no limit Both N18 Chronic renal failure Treatment - Drugs Placebo In the experimental group allopurinol 100 mg will be given under the supervision of nephrologist ,daily for 12 months. Then at beginning of the study, and at 3,6 and 12 months the kidney function of patients with GFR, uric acid and creatinine is assessed. In the control group will receive 100 mg of placebo daily for 12 months. Then at beginning of the study, and at 3,6 and 12 months the kidney function of patients with GFR, uric acid and creatinine is assessed. GFR level. Timepoint: At beginning of the study, and at 3,6 and 12 months after study. Method of measurement: Using the formula Modification of Diet in Renal Disease(MDRD). Using the formula creatinine. Timepoint: At beginning of the study, and at 3,6 and 12 months after study. Method of measurement: Based on blood tests. Uric acid. Timepoint: At beginning of the study, and at 3,6 and 12 months after study. Method of measurement: Based on blood tests. Vice chancellor for research, Kermanshah University of Medical Sciences Approved 2014-10-14 Ethics committee of Kermanshah University of Medical Sciences Building No.2, Shahid Beheshti, Vice Chancellor for Research Affairs, Kermanshah University of Medical Sciences Kermanshah Iran (Islamic Republic of)