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IRCT2015102314215N2 IRCT 2015-12-21 Vice chancellor for research, Ahvaz Jundishapur University of Medical Sciences Comparison of Conservative with Conventional Management in Newborns with Diagnosis of Transient Tachypnea of Newborns Comparison of Conservative with Conventional Management on Hospitalization Period in Newborns with Diagnosis of Transient Tachypnea of Newborns 2015-05-10 anticipated 130 Complete https://irct.ir/trial/13859 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 PREVENTIVE. Intervention 1: in intervention group DW10% 60ml/kg/d will be prescribed and increases by 20ml/kg/d till 100ml/kg/d. sodium chloride 3meq/kg/d and potassium chloride 2meq/kg/d will be added to fluid from second day of life. oxygen or NCPAP will be used base on severity of respiratory distress. Intervention 2: in control group DW10% 60ml/kg/d will be prescribed and increases by 20ml/kg/d till 100ml/kg/d. sodium chloride 3meq/kg/d and potassium chloride 2meq/kg/d will be added to fluid from second day of life. oxygen or NCPAP will be used base on severity of respiratory distress. also ampicillin 150mg/kg/day in three divided doses and gentamycin 7.5mg/kg/day in two divided doses till determination of blood culture will be prescribed.
public Masoud Dehdashtian
Imam Khomeini Hospital, Azadegan street, Ahvaz, Khozestan Province, IRAN
Ahvaz Iran (Islamic Republic of) 6155818747 +98 61 3338 9669 dehdashtian@ajums.ac.ir; m.dehdashtian@gmail.com Ahvaz Jundishapur University of Medical Sciences scientific Masoud Dehdashtian
Imam Khomeini Hospital, Azadegan street, Ahvaz, Khozestan Province, IRAN
Ahvaz Iran (Islamic Republic of) +98 61 3338 9669 dehdashtian@ajums.ac.ir; m.dehdashtian@gmail.com Ahvaz Jundishapur University of Medical Sciences Iran (Islamic Republic of) Inclusion Criteria: gestational age 34- 0/7 and 41- 6/7; respiratory rate>60/min at first 6 hours of life; persistence of tachypnea for at least 12 hours; appropriate radiographic findings for transient tachypnea of newborns; absence of history of meconium staining; fetal distress; mother's fever; rupture of membrane>18 hours Exclusion Criteria: blood sugar<50mg%; serum calcium<7mg%; hematocrit>60%; hemoglobin<13.5g%; white blood counts<5000/cumm; white blood counts>20000/cumm; absolute neutrophil counts<1750/cumm; immature to mature neutrophil counts ratio>0.2; platelet counts<150000/cumm; positive blood culture; needing to mechanical ventilation; c-reactive proteins>10mg/ml no limit 1 day Both P02.7, P03 Fetus and newborn affected by chorioamnionitis: Amnionitis; Membranitis; Placentitis, Fetus and newborn affected by caesarean delivery Prevention Treatment - Drugs in intervention group DW10% 60ml/kg/d will be prescribed and increases by 20ml/kg/d till 100ml/kg/d. sodium chloride 3meq/kg/d and potassium chloride 2meq/kg/d will be added to fluid from second day of life. oxygen or NCPAP will be used base on severity of respiratory distress. in control group DW10% 60ml/kg/d will be prescribed and increases by 20ml/kg/d till 100ml/kg/d. sodium chloride 3meq/kg/d and potassium chloride 2meq/kg/d will be added to fluid from second day of life. oxygen or NCPAP will be used base on severity of respiratory distress. also ampicillin 150mg/kg/day in three divided doses and gentamycin 7.5mg/kg/day in two divided doses till determination of blood culture will be prescribed. Duration of admission. Timepoint: discharge. Method of measurement: hour. Duration of NCPAP therapy. Timepoint: Continuous. Method of measurement: Hour. Oxygen therapy. Timepoint: Continuous. Method of measurement: Hour. Vice chancellor for research, Ahvaz Jundishapur University of Medical Sciences Approved 2015-05-09 Ethic Comite of Ahvaz Jundishapur University of Medical Sciences Ahvaz Jundishapur Univerity of Medical Sciences, Golestan st., Ahvaz, Khozestan Province, IRAN Ahvaz Iran (Islamic Republic of)