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IRCT2014052114190N3 IRCT 2014-06-17 Vice Chancellor for Research and Technology Development-Ahwaz Jondishapur University of Medical Sci The effect of Hydroxyethyl Starch (Voluven) On Hemorrhagic Shock Treatment. Comparison the effectiveness of hydroxyethyl starch (voluven) solution versus normal saline in hemorrhagic shock treatment in trauma 2013-09-23 anticipated 100 Complete https://irct.ir/trial/13836 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 3 Hemorrhagic Shock. Intervention 1: First, a sample of the patient's arterial blood gas (ABG) is drawn. Afterwards the intervention group was treated with 1.000 cc normal saline and 500cc hydroxyethyl starch. After an hour, arterial blood gas was reevaluated. Voluven consumption was determined according to the protocol of the Scientific Society of Emergency Medicine. A questionnaire will be completed for each patient as well. Intervention 2: First, a sample of the patient's arterial blood gas (ABG) is drawn. Afterwards the control group was treated with 2.000 cc normal saline. After an hour, arterial blood gas was reevaluated. A questionnaire will be completed for each patient as well.
public Dr. Ali Reza Rafati Navaei
Ahvaz Jundishapur University of Medical Sciences, University City, Ahvaz
Ahvaz Iran (Islamic Republic of) 1579461357 +98 61 1333 3477 ali_rafaty@yahoo.com Ahvaz Jundishapur University of Medical Sciences scientific Dr. Ali Asgari Darian
Ahvaz Jundishapur University of Medical Sciences, University City, Ahvaz
Ahvaz Iran (Islamic Republic of) +98 61 1374 3037 alibehdad@aol.com Department of Emergency Medicine, Ahvaz Jundishapur University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: The study included all patients with traumatic hemorrhagic shock who were referred to the Imam Khomeini hospital in Ahvaz, Iran. Exclusion criteria: Heart failure (reduced heart function with clinical symptoms: orthopnea, exertional dyspnea, MET <4 and EF <50%); Patient who received Blood before the study completed; Patient died before completing the study; Sensitivity to serum; Transfer to the operating room before the study completed; Hepatic insufficiency (decreased liver function with decreased albumin, increased PT, clinical and liver enzymes could be increased more than 5 times); Respiratory failure (lung function decline with increasing Pco2> 50 or drop in Po2 <60 or observed clinical signs of respiratory distress); Renal impairment: decreased renal function (GFR <60 mL/min/1.73 m2 for at least three months, or significant proteinuria); Sepsis: The presence of SIRS (Systemic Inflammatory Response Syndrome) with prove microbial etiology; Severe anemia (Hb <10); Patients who are considered for the diagnosis of non hemorrhagic shock; Patients with a history of sensitivity to the Solutions used in this study. 18 years 70 years Both R57.9 Failure of peripheral circulation NOS Treatment - Drugs Treatment - Drugs First, a sample of the patient's arterial blood gas (ABG) is drawn. Afterwards the intervention group was treated with 1.000 cc normal saline and 500cc hydroxyethyl starch. After an hour, arterial blood gas was reevaluated. Voluven consumption was determined according to the protocol of the Scientific Society of Emergency Medicine. A questionnaire will be completed for each patient as well. First, a sample of the patient's arterial blood gas (ABG) is drawn. Afterwards the control group was treated with 2.000 cc normal saline. After an hour, arterial blood gas was reevaluated. A questionnaire will be completed for each patient as well. Base Excess. Timepoint: Before and after fluid therapy. Method of measurement: Measured by drawing a sample of arterial blood gas (ABG). Shock Index. Timepoint: after serum therapy. Method of measurement: If the shock index (heart rate / systolic blood pressure) is greater than one is considered positive. Vice Chancellor for Research and Technology Development-Ahwaz Jondishapur University of Medical Sci Approved 2013-05-25 Ethics committee of Ahvaz Jundishapur University of Medical Sciences Ahvaz Jundishapur University of Medical Sciences, University City, Ahvaz Ahvaz Iran (Islamic Republic of)