IRCT2016101313785N3 IRCT 2016-12-30 Vice Chancellor of research of Iran University of Medical Sciences The effect of fresh frozen plasma on rotational thromboelastometry (Rotem) parameters and received blood products in children under cardiac surgery Effect of fresh frozen plasma for priming cardiopulmonary bypass machine on rotational thromboelastometry (Rotem) parameters and received blood products in children undergoing cardiac surgery 2016-04-03 anticipated 84 Complete https://irct.ir/trial/13565 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Other design features: Random allocation by random number table. N/A Cardiovascular Disease. Intervention 1: Intervention group: ّor every kg of body weight, 10-20 ml fresh frozen plasma (FFP) and 100-200 ml crystalloid solution (Ringer dolurion) will be used as priming solution. To maintain hematocrit at 20 percent, all patients will receive packed cell. remaining of the cardiovascular bypass process would be the same for both groups. After surgery, to alleviate the effect of heparin, 1 mg Protamin/ kg body weight will be injected and then the patient will be weaned from bypass machine. Intervention 2: Control group: For every kg of body weight, 10-20 ml hydroxyethyl starch with proportion of 130 to 0.4 and 100-200 ml crystalloid solution (Ringer dolurion) will be used as priming solution. To maintain hematocrit at 20 percent, all patients will receive packed cell. Remaining of the cardiovascular bypass process would be the same for both groups. After surgery, to alleviate the effect of heparin, 1 mg Protamin/ kg body weight will be injected and then the patient will be weaned from bypass machine.