]>
IRCT201403041774N6 IRCT 2014-12-07 Physiology research center, Vice chancellor for Research and Technology of kerman medical University Insulin glargine and acarbose in the treatment of type II diabetes comparison of the effect of insulin glargine on glycemic control when combined with either metformin or acarbose in Type 2 diabetic patients 2014-08-02 anticipated 152 Complete https://irct.ir/trial/1351 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2-3 Diabet mellitus. Intervention 1: The first group (group A) uses placebo metformin and placebo Acarbose. Intervention 2: The second group (group B) takes 500-mgl metformin pills every night; the drug dose increases for 2 grams every week, and they also use placebo Acarbose. Intervention 3: The third group (group C) use 100 mg of Acarbose pill. The dose in the first week is 50 and then 100 mg for each meal (utmost daily doze is 300 mg); they also use metformin placebo. Intervention 4: The fourth group (group D) uses metformin and Acarbose pill.
public Dr. Mojgan Sanjari
AfzaliPour Hospital, Adjacent to Bahonar University, AfzaliPour Landscape, Imam highway, Kerman
kerman Iran (Islamic Republic of) 7616913911 +98 34 1322 2250 msanjari@kmu.ac.ir Associated professor scientific Dr. Mojgan Sanjari
AfzaliPour Hospital, Adjacent to Bahonar University, AfzaliPour Landscape, Imam highway, Kerman
Kerman Iran (Islamic Republic of) 7616913911 +98 34 1322 2250 msanjari@kmu.ac.ir Kerman Afzalipour Hospital Iran (Islamic Republic of) Inclusion criteria: 1. Type 2 diabetes (based on American Diabetes Association criteria) 2. age group 18-75 years 3. Enough acuity and alertness to injection of insulin 4. no glycemic control with oral medications Exclusion criteria: 1. Chronic Complications of Diabetes 2. Pregnancy 3. Breastfeeding 4. Liver Disease 5. kidney disease 6. neurological disease 7. chronic inflammatory disease 18 years 75 years Both E11 non insulin dependent diabetes mellitus Placebo Placebo Placebo Treatment - Drugs The first group (group A) uses placebo metformin and placebo Acarbose The second group (group B) takes 500-mgl metformin pills every night; the drug dose increases for 2 grams every week, and they also use placebo Acarbose. The third group (group C) use 100 mg of Acarbose pill. The dose in the first week is 50 and then 100 mg for each meal (utmost daily doze is 300 mg); they also use metformin placebo. The fourth group (group D) uses metformin and Acarbose pill. Plasma glucose. Timepoint: During of study. Method of measurement: Blood sample. HbA1c. Timepoint: 0, 90. Method of measurement: Blood sample. Hypoglycemia. Timepoint: Self - monitoring of blood glucose. Method of measurement: Questionnaire and blood tests during raid. Laboratory Tests. Timepoint: Before and one month, two months, three months after the intervention. Method of measurement: blood and urine sample. Weight and blood prussre and others. Timepoint: Before and one month, two months, three months after the intervention. Method of measurement: Barometer system and standard weight. Excir company Physiology research center, Vice chancellor for Research and Technology of kerman medical University Excir company Approved 2013-12-04 Ethics Committee Vice chancellor for Research and Technology of kerman university of medical science In front of Besat clinic, the begining of Ebn-e-Sina street, the begining of Jahad Boulevard, Tahmasb Abad crossroads, Physiology research center, Vice chancellor for Research and Technology of University of Medical Sciences, kerman kerman Iran (Islamic Republic of)