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IRCT2017042613678N27 IRCT 2017-06-26 Vice Chancellor for research of Urmia university of medical sciences Effect of vitamin D on inflammation and muscle damage in athletes Evaluating the effect of Cholecalciferol supplementation on inflammatory markers and muscle damage indices in soccer players after a simulated soccer match 2016-08-21 anticipated 22 Complete https://irct.ir/trial/13468 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomization method was Balanced block. N/A Condition 1: inflammation. Condition 2: muscle damage. Intervention 1: Experimental group will receive supplement for 8 weeks (each week they should eat one 50000 IU cholecalciferol pearl). After 8 weeks, players will participate in a simulated soccer match at the test day. The protocol of the simulated soccer match is according to Loughbrough intermittent shuttle run test. The test comprised two parts, Part A and Part B. Part A was of a fixed duration and consisted of five 15 min exercise periods separated by 3 min of recovery. The exercise periods consisted of a set pattern of intermittent high-intensity running, and were designed to be similar to the activity pattern typically recorded for soccer match play. The pattern of exercise for Part A was as follows: 3 ´ 20 m at walking pace; 1 ´ 20 m at maximal running speed; 4 s recovery; 3 ´ 20 m at a running speed corresponding to 55% of individual VO2max; 3 ´ 20 m at a running speed corresponding to 95% of individual VO2max This pattern of exercise was repeated for each 15 min block followed by a rest period of 3 min. Altogether, five15 min exercise blocks were completed, separated by 3 min of recovery, before the start of Part B. Part B was an open-ended period of intermittent shuttle running, designed to exhaust the participants within approximately 15 min. The participants were required to run at speeds corresponding to 55% and 95% of predicted VO2max , the speed alternating every 20 m. This pattern of exercise was repeated continuously until the participants were unable to maintain the required speed for two consecutive shuttles at the higher of the two exercise intensities. Intervention 2: Control group will receive placebo for 8 weeks (each week they should eat one oral paraffin pearl). After 8 weeks, players will participate in a simulated soccer match at the test day. The protocol of the simulated soccer match is according to Loughbrough intermittent shuttle run test. The test comprised two parts, Part A and Part B. Part A was of a fixed duration and consisted of five 15 min exercise periods separated by 3 min of recovery. The exercise periods consisted of a set pattern of intermittent high-intensity running, and were designed to be similar to the activity pattern typically recorded for soccer match play. The pattern of exercise for Part A was as follows: 3 ´ 20 m at walking pace; 1 ´ 20 m at maximal running speed; 4 s recovery; 3 ´ 20 m at a running speed corresponding to 55% of individual VO2max; 3 ´ 20 m at a running speed corresponding to 95% of individual VO2max This pattern of exercise was repeated for each 15 min block followed by a rest period of 3 min. Altogether, five15 min exercise blocks were completed, separated by 3 min of recovery, before the start of Part B. Part B was an open-ended period of intermittent shuttle running, designed to exhaust the participants within approximately 15 min. The participants were required to run at speeds corresponding to 55% and 95% of predicted VO2max , the speed alternating every 20 m. This pattern of exercise was repeated continuously until the participants were unable to maintain the required speed for two consecutive shuttles at the higher of the two exercise intensities.
public Saeed Ghavamzadeh
Medicine college, Urmia university of medical sciences, Nazloo road
Urmia Iran (Islamic Republic of) - +98 440000000 ghavamzadeh@hotmail.com Urmia university of medical sciences scientific Dr Saied Ghavamzadeh
Nutrition Department, Faculty of Medicine, Urmia University of Medical Science, 11th km of Nazloo Road, Urmia
Urmia Iran (Islamic Republic of) - +98 44 3278 0803 ghavamzadeh_s@yahoo.com; ghavamzadeh@hotmail.com Urmia University of Medical Sciences Iran (Islamic Republic of) inclusion criteria: soccer players who want to collaboration; players who regularly and consistently participate in soccer practices and matches(at least 4 month passed from starting this sport); age group between 18 to 30 years old; healthy players without any injury, cardio-metabolic disease, orthopedic and inflammatory disease; players without any acute liver disease, biliary, kidney and digestive disease; players with no history of kidney stone and hyperparathyroidism and osteomalasia or osteoporosis and sarcoidosis; lack of vitamin D supplementation at least for 8 weeks before the study beginning; lack of using drugs which can affect vitamin D level and its metabolism and function such as steroid and anti-epileptic drugs; lack of using certain drugs such as acetaminophen and anti-inflammatory drugs and b blockers and statins; lack of using exogenous hormones; lack of using amphotericin B,ampicilin, anticoagulant drugs, aspirin, clofibrate, cocaine, lithium, furosemide, morphine and some of anesthetic drugs; lack of using epinephrine and sodium bicarbonate; lack of using orlistate and cholestyramine and other cholesterol reducing drugs; people by BMI group 18.5 to 30; lack of smoking and alcohol consumption; people with 25(oh)D serum concentration less than 40 ng/mL. exclusion criteria: lack of collaboration for continuing the study; using certain drugs during the study; using foods rich in vitamin D specially canned fish, cod fish oil, Salmon and vit D fortified foods; using less than 80 % of supplements; traveling to place with sunny weather during the study; injury or disease occurrence during the study. 18 years 30 years Male - - - - Treatment - Other Treatment - Other Experimental group will receive supplement for 8 weeks (each week they should eat one 50000 IU cholecalciferol pearl). After 8 weeks, players will participate in a simulated soccer match at the test day. The protocol of the simulated soccer match is according to Loughbrough intermittent shuttle run test. The test comprised two parts, Part A and Part B. Part A was of a fixed duration and consisted of five 15 min exercise periods separated by 3 min of recovery. The exercise periods consisted of a set pattern of intermittent high-intensity running, and were designed to be similar to the activity pattern typically recorded for soccer match play. The pattern of exercise for Part A was as follows: 3 ´ 20 m at walking pace; 1 ´ 20 m at maximal running speed; 4 s recovery; 3 ´ 20 m at a running speed corresponding to 55% of individual VO2max; 3 ´ 20 m at a running speed corresponding to 95% of individual VO2max This pattern of exercise was repeated for each 15 min block followed by a rest period of 3 min. Altogether, five15 min exercise blocks were completed, separated by 3 min of recovery, before the start of Part B. Part B was an open-ended period of intermittent shuttle running, designed to exhaust the participants within approximately 15 min. The participants were required to run at speeds corresponding to 55% and 95% of predicted VO2max , the speed alternating every 20 m. This pattern of exercise was repeated continuously until the participants were unable to maintain the required speed for two consecutive shuttles at the higher of the two exercise intensities. Control group will receive placebo for 8 weeks (each week they should eat one oral paraffin pearl). After 8 weeks, players will participate in a simulated soccer match at the test day. The protocol of the simulated soccer match is according to Loughbrough intermittent shuttle run test. The test comprised two parts, Part A and Part B. Part A was of a fixed duration and consisted of five 15 min exercise periods separated by 3 min of recovery. The exercise periods consisted of a set pattern of intermittent high-intensity running, and were designed to be similar to the activity pattern typically recorded for soccer match play. The pattern of exercise for Part A was as follows: 3 ´ 20 m at walking pace; 1 ´ 20 m at maximal running speed; 4 s recovery; 3 ´ 20 m at a running speed corresponding to 55% of individual VO2max; 3 ´ 20 m at a running speed corresponding to 95% of individual VO2max This pattern of exercise was repeated for each 15 min block followed by a rest period of 3 min. Altogether, five15 min exercise blocks were completed, separated by 3 min of recovery, before the start of Part B. Part B was an open-ended period of intermittent shuttle running, designed to exhaust the participants within approximately 15 min. The participants were required to run at speeds corresponding to 55% and 95% of predicted VO2max , the speed alternating every 20 m. This pattern of exercise was repeated continuously until the participants were unable to maintain the required speed for two consecutive shuttles at the higher of the two exercise intensities. Interleukin 6. Timepoint: at the end of the trial: before the simulated test, immediately after the test, 2 and 24 hours after the test. Method of measurement: lab test. CRP. Timepoint: at the end of the trial: before the simulated test, immediately after the test, 2 and 24 hours after the test. Method of measurement: lab test. Lactate dehydrogenase. Timepoint: at the end of the trial: before the simulated test, immediately after the test, 2 and 24 hours after the test. Method of measurement: lab test. Creatine phosphate kinase. Timepoint: at the end of the trial: before the simulated test, immediately after the test, 2 and 24 hours after the test. Method of measurement: lab test. Serum 25-oh vitamin D3 level. Timepoint: before and after the trial: immidiately before the soccer simulated test. Method of measurement: lab test. Body composition. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Body composition analyzer (BIA). Rating of Perceived Exertion. Timepoint: immidiately after each partof the simulated test. Method of measurement: questionnaire. - - Vice Chancellor for research of Urmia university of medical sciences Approved 2016-10-26 Ethics committee of Urmia University of Medical Sciences urmia, staff of urmia university of medical sciences urmia Iran (Islamic Republic of)