]>
IRCT2014070613456N1 IRCT 2014-08-14 Vice chancellor for research of Guilan University of Medical Sciences Reduction or prevention of Myoclonus after Etomidate infusion The comparison of the effect of pretreatment with low dose of midazolam, low dose of etomidate, remifentanyl and sulfate magnesium on reduction or prevention of myoclonus after etomidate induction in orthopedic surgery 2014-08-23 anticipated 284 Complete https://irct.ir/trial/13324 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. 2-3 Myoclonus. Intervention 1: Intervention1: Injection of low dose of Midazolam 0.015mg/kg as a premed before Etomidate. Intervention 2: Intervention 2: Injection of sulfate magnesium 30 mg/kg before induction of anesthesia with Etomidate. Intervention 3: Intervention 3: Injection of Remifentanyl 1 micg/kg before Etomidate. Intervention 4: Intervention 4: Injection of low dose of Etomidate 0.03 mg/kg before induction of anesthesia with Etomidate.
public Abbas Sedighinejad
Poursina Hospital
Rasht Iran (Islamic Republic of) 4193713194 +98 13 1322 3960 arcguilan1392@gums.ac.ir;a_sedighinejad@gums.ac.ir Guilan University of Medical Sciences scientific Abbas Sedighinejad
Poursina hospital
Rasht Iran (Islamic Republic of) 4139638459 +98 13 1322 3960 arcguilan1392@gmail.com;A_sedighinejad@gums.ac.ir Guilan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: ASA ( American Society of Anesthesiologists) I, II; age between 18 to 59 years old. Exclusion criteria: patients with Neurological problems; allergy; those who have received sedative or analgesic drugs in the 24 hours ago. 18 years 59 years Both G25.3 Drug-induced myoclonus Prevention Prevention Prevention Prevention Intervention1: Injection of low dose of Midazolam 0.015mg/kg as a premed before Etomidate Intervention 2: Injection of sulfate magnesium 30 mg/kg before induction of anesthesia with Etomidate Intervention 3: Injection of Remifentanyl 1 micg/kg before Etomidate Intervention 4: Injection of low dose of Etomidate 0.03 mg/kg before induction of anesthesia with Etomidate Myoclonus. Timepoint: Within 90 seconds after injection of Etomidate as the main drug for induction of anesthesia. Method of measurement: Myoclonus Grade. Vice chancellor for research of Guilan University of Medical Sciences Approved 2014-07-14 Ethics committee of Guilan university of Medical Sciences Namjoo street Rasht Iran (Islamic Republic of)