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IRCT2013101313442N4 IRCT 2013-11-01 Physical Medicine and Rehabilitation Departement of Shahid Beheshti University of Medical Science Effects of local Progesterone injection versus Corticosteroid injection in patients with Carpal Tunnel Syndrome Study of the effects of local Progesterone injection versus Corticosteroid injection in patients with mild and moderate Carpal Tunnel Syndrome in Physical Medicine and Rehabilitation clinic of Modarres and shohadaie Tajrish Hospitasls from 2012 to 2013 2012-12-21 anticipated 60 Complete https://irct.ir/trial/13298 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Carpal Tunnel Syndrome. Intervention 1: Single injection of 1 ml of Triamcinolon with 2cc syringe and Prefabricated hand wrist splint for CTS for 8 weeks. Intervention 2: Single injection of 1 ml 17 Alpha Hydroxiprogesterone with 2cc syringe and Prefabricated hand wrist splint for CTS for 8 weeks.
public Shadi Shahraeeni
Shahid Modarres hospital, Kaj square, Saadat abad street
Tehran Iran (Islamic Republic of) +98 21 2207 4090 dr.shahraeeni@gmail.com Modarres Hospital scientific Seyed Ahmad Raeissadat
Shahid Modarres Hospital, Kaj square, Saadat Abad street
Tahran Iran (Islamic Republic of) +98 21 2207 4090 a_raeissadat@sbmu.ac.ir Shahid Modarres Hospital Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion Criteria: patient with mild and moderate CTS confirmed by the presence of 1 or more of the following standard electrophysiological criteria:1- prolonged distal motor latency (DML) (abnormal ≥4.2 ms)of Median nerve and 2) prolonged antidromic distal sensory latency (DSL) to the third digit (abnormal >3.6 ms; age between 20 to 65 years old. Exclusion criteria:Pregnancy; Severe degree CTS; Background metabolic diseases such as: Diabetes mellitus; Hypothyroidism; Rheumatoid arthritis; Previous history of Corticosteroid injection in Carpal Tunnel; Severe atrophy of Thener muscles; cervical radiculopathy or significant polyneuropathy; Unwillingness to participate in the present study; patient younger than 20 or older than 65 years old. 20 years 65 years Female G56.0 Carpal Tunnel Syndrome Treatment - Drugs Treatment - Drugs Single injection of 1 ml of Triamcinolon with 2cc syringe and Prefabricated hand wrist splint for CTS for 8 weeks Single injection of 1 ml 17 Alpha Hydroxiprogesterone with 2cc syringe and Prefabricated hand wrist splint for CTS for 8 weeks Pain. Timepoint: 0,10 weeks, 6 months. Method of measurement: Visual Analog Scale, that is from 0-10 and zero (0) means that you did not have any pain and ten (10) means that you had the worst pain imaginable. Functional Status. Timepoint: 0, 6weeks, 6months. Method of measurement: Bostone/levine Functional Status Scale Questionnare. Symptome Severity(pain and paresthesia). Timepoint: 0,10weeks, 6months. Method of measurement: Bostone/levine Symptome Severity Scale Questionnare. Distal Sensory Peak Latency(SNAP) of median nerve. Timepoint: 0,10weeks, 6months. Method of measurement: EDX Indexes. Distal Motor Onset Latency(CMAP) of median nerve. Timepoint: 0,10weeks, 6months. Method of measurement: EDX indexes. Patient Satisfication after trearment. Timepoint: 0,10weeks, 6months. Method of measurement: Patient statement. Physical Medicine and Rehabilitation Departement of Shahid Beheshti University of Medical Science Approved 2012-12-09 Ethic committe of faculty of Medicine,Shahid Beheshti University of Medical siences Shahid Beheshti University of Medical siences, next to Taleghani Hospital, yaman street, Chamran Highway Tehran Iran (Islamic Republic of)