IRCT138712291772N2 IRCT 2010-05-31 Tabriz medical university Post operative pain management Multimodal Preincisional Early Premedication to Prevent Pain After Cholecystectomy 2009-05-01 anticipated 60 Complete https://irct.ir/trial/1326 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Other design features: Impact on reducing opium use in the ward. 3 Condition 1: Cholecystitis and cholelithiasis. Condition 2: opioid consumption. Intervention 1: Control group: instead of Diclofenac, Clonidine and Ketamine they received placebo before the operation, but the surgical site infiltrated with Bupivacaine 0.25% before incision. Intervention 2: Intervention group received Diclofenac suppository 100 mg, Clonidine 0.2 mg half an hour before surgery and Ketamine 50 mg IV after induction of anesthesia. Site of Incision were infiltrated before the incision with Bupivacaine 0.25%.