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IRCT2013042013069N1 IRCT 2013-09-22 Kermanshah University of Medical Sciences, Vice chancellor for research Suppository indomethacin and combined indomethacin- acetaminophen for pain after cesarean section Comparison of suppository indomethacin and combination of indomethacin- acetaminophen on post operative pain after cesarean section 2013-03-06 anticipated 76 Complete https://irct.ir/trial/13005 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Other design features: Women randomized into two groups by 1:1 ratio using a computer-generated random numbers. ‎Physician who evaluates the pain is blind to treatment interventions. 3 Post-cesarean pain. Intervention 1: Group A: A 50-mg indomethacin rectal suppository is administered immediately after a cesarean every 6 hours for 24 hours after the operation. Intervention 2: Group B: Two rectal suppositories (A 50-mg indomethacin and a 325-mg acetaminophen) are administered immediately after cesarean every 6 hours for 24 hours after the operation.
public Dr. Mohammad Rasoul Ghadami
Imam Reza hospital, Sorkheh lizheh
Kermanshah Iran (Islamic Republic of) +98 83 1427 6310 mrghadami@kums.ac.irmr_ghadami@yahoo.com Kermanshah University of Medical Sciences scientific Dr. Mohammad Rasoul Ghadami
Imam Reza hospital, Sorkheh lizheh
Kermanshah Iran (Islamic Republic of) +98 83 1427 6310 mrghadami@kums.ac.irmr_ghadami@yahoo.com Kermanshah University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria include elective cesarean section with lower uterine segment incision; pregnancy over 37 weeks. Exclusion criteria include anemia, multiple pregnancies, poly hydramnious, prolonged labor, premature rupture of membranes, diabetes, high blood pressure, renal disease, history of drug abuse or smoking, cardiovascular diseases and coagulation disorders. or other underlying diseases. 18 years 45 years Female O82.9 Delivery by caesarean section, unspecified Treatment - Drugs Treatment - Drugs Group A: A 50-mg indomethacin rectal suppository is administered immediately after a cesarean every 6 hours for 24 hours after the operation. Group B: Two rectal suppositories (A 50-mg indomethacin and a 325-mg acetaminophen) are administered immediately after cesarean every 6 hours for 24 hours after the operation. Pain severity. Timepoint: 2, 4, 6, 12, 24 h after operation. Method of measurement: VAS with a 10-cm ruler is used and patient shows her pain on the ruler. Nausea and vomiting, need for analgesic and anti-emetic. Timepoint: 2, 4, 6, 12, 24 h after operation. Method of measurement: Ask from patient by resident. Kermanshah University of Medical Sciences, Vice chancellor for research Approved 2013-03-05 Ethics committee, Kermanshah University of Medical Sciences Shahid beheshti Blvd. Build no. 2 Kermanshah Iran (Islamic Republic of)