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IRCT2013040912958N1 IRCT 2013-06-17 Tehran University of Medical Sciences Misoprostol in therapeutic abortion - Comparison of vaginal and sub-lingual misoprestol for induction of therapeutic abortion at 12- 20 weeks gestational age 2012-13 2012-04-01 anticipated 480 Complete https://irct.ir/trial/12938 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Therapeutic abortion. Intervention 1: In group A, patients received 400 mg of sub-lingual misoprestol every 6 hours to induce abortion and administration was discontinued in cases of severe contraction. Intervention 2: Group B, received 400 mg of vaginal tablet of misoprestol, placing in the vagina every 6 hours and treatment carried on until delivery of fetus or induction of severe contractures.
public Nazila Mesbah
Dr.Ali Shariati Hospital, North Karegar St.
Tehran Iran (Islamic Republic of) - +98 21 8490 2414 nazila.mesbah@yahoo.com Tehran University of Medical Sciences scientific Nazila Mesbah
Dr.Ali Shariati, North Karegar St.
Tehran Iran (Islamic Republic of) - +98 21 8490 2414 nazila.mesbah@yahoo.com Tehran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria : All pregnant women with gestational age between 12 and 20 weeks who have medical indications for pregnancy termination 20-40 years old including fetal indications like structural or chromosomal fetal abnormalities, PROM, intrauterine fetal death or maternal indication such as pregnant women with hemoglobin less than 10 mg. Exclusion Criteria: pregnant women with any type of allergic reaction to misoprestol, pregnant women high risk for rupture of uterine, history of classic uterine incision or T-shaped incision, women with a history of extensive surgery on the fundus of the uterus, pregnant women with IUD, women with certain medical conditions such as severe anemia, clotting disorders or taking anticoagulant medication, active liver disease, glaucoma, uncontrolled seizure disorders, adrenal disease or disorder that requires treatment with glucocorticoids such as tracheobronchial asthma, Smoking more than 20 cigarettes per day, gynecologic abnormalities confirmed by ultrasound, mitral stenosis, sickle cell anemia, diastolic blood pressure more than 90 mm Hg, systolic pressure less than 90 mmHg, history of thromboembolism and liver disease, hemolytic disorders and a history of two cesareans. 20 years 40 years Female O04 Therapeutic Abortion Treatment - Drugs Treatment - Drugs In group A, patients received 400 mg of sub-lingual misoprestol every 6 hours to induce abortion and administration was discontinued in cases of severe contraction. Group B, received 400 mg of vaginal tablet of misoprestol, placing in the vagina every 6 hours and treatment carried on until delivery of fetus or induction of severe contractures. Complete evacuation of products of conception. Timepoint: 24-48 h. Method of measurement: Questinaire. Pulse rate. Timepoint: 24 and 48 hr. Method of measurement: examination. Blood pressure. Timepoint: 24 and 48 hr. Method of measurement: examination. Uterine contraction. Timepoint: 24 and 48 hr. Method of measurement: examination. Mean induction to delivery time. Timepoint: 24 and 48 hr. Method of measurement: Questionaire. Occurrence of side effects. Timepoint: 24 and 48 hr. Method of measurement: Questionaire. Tehran University of Medical Sciences Approved 2012-05-26 Ethics Committee, Faculty of Medicine Faculty of Medicine, Tehran University of Medical Sciences and Health Care Tehran Iran (Islamic Republic of)