]>
IRCT2013040312888N1 IRCT 2013-06-20 Tabriz University of Medical Sciences The effect of mannitol in reducing brain edema and increasing the level of consciousness in patients with brain injury Effect of 0.5, 1, 1.5 g / kg doses of monnitol 20% in reduction of brain edema and increase in post-traumatic consciousness level in patients with diffuse axonal injury accompanied with edema and brain midline shifting more than 5 mm 2010-04-21 anticipated 30 Complete https://irct.ir/trial/12893 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Diffuse brain injury. Intervention 1: mannitol 20% 0.5 mg/kg WB. Intervention 2: Mannitol%20 1g/kg WB. Intervention 3: mannitol%20 1.5g/kg WB.
public
scientific Asghari Mohammad
Emam Reza Educational and Training Hospital
Tabriz Iran (Islamic Republic of) +98 41 1334 0830 ebrahimihadi@yahoo.com Tabriz University of Medical Sciences Iran (Islamic Republic of) (Inclusion criteria: age 15 to 60 years, patients with diffuse axonal injury: level of consciousness of less than 8; edema and brian shifting from midline of more than 5 mm; willingness to participate in the study. Exclusion criteria: renal failure, intense electrolyte imbalance; death throughout the study) 15 years 60 years Both s06.2 Diffuse brain injury Treatment - Drugs Treatment - Drugs Treatment - Drugs mannitol 20% 0.5 mg/kg WB Mannitol%20 1g/kg WB mannitol%20 1.5g/kg WB Brain edema severity. Timepoint: On admission and 48 hours after admission. Method of measurement: Brain edema will be meseaured by CT scan on admission and 48 hours after admission and the findings will be graded based on the cistern basal being open, semi-open and close from1-3. Brain midline shift. Timepoint: On admission and 48 hours after admission. Method of measurement: Brain edema will be meseaured by CT scan on admission and 48 hours after admission and will be calculated based on the midline shifting formula.(middle shift=biparietal diametr-2SP). Level of consciousness. Timepoint: On admission and 48 hours after admission. Method of measurement: The GCS Glasgow Coma Scale score of 3 to 15 have been measured to be between. Tabriz University of Medical Sciences Approved 2011-05-01 Research Deputyof Faculty Medicine Research Department, 3rd floor of 2nd central bulding of Tabriz university of Medical Sciences, Daneshghah Ave. Tabriz Iran (Islamic Republic of)