IRCT2013032212847N1 IRCT 2013-05-29 Vice Chancellor for Research, Shahid Sadoghi University of Medical Science The effect of Doxycycline on periodontal treatment in diabetics and non diabetics Evaluating the effect of sub-antimicrobial dose Doxycycline as an adjuvant on periodontal treatments in diabetics and non diabetics 2013-01-07 anticipated 32 Complete https://irct.ir/trial/12868 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Indeed, this study is in the form of two Clinical Trial Studies, which are concurrently done in order to evaluate the effect of Doxycycline 20 mg on periodontal treatment of diabetic and non diabetic patients. Diabetic and non diabetic patients were randomly divided into two interventional and control groups, even numbers added to intervention group and odd numbers added to control group. The intervention in this study is Doxycycline capsules as scaling and root planning is done for all patients. 2-3 Moderate to Severe Chronic Periodontitis. Intervention 1: Scaling and root planning is done by an ultrasonic device (China, Woodpecker) for diabetic patients in interventional group 1, then oral Doxycycline 20 mg which was made by a drugstore as much as need for this study is prescribed bid (every 12 hours( for 3 months. It is available in capsules by dose of 100 mg in Iran, but by mixing the content of 100 mg capsules with the starch doses of 20 mg has been identified. Intervention 2: Scaling and root planning is done by an ultrasonic device (China, Woodpecker) for diabetic patients in interventional group 2. Intervention 3: Scaling and root planning is done by an ultrasonic device (China, Woodpecker) for non diabetic patients in interventional group 3, then Doxycycline 20 mg which was made by a drugstore is prescribed bid for 3 months. Intervention 4: Scaling and root planning is done by an ultrasonic device (China, Woodpecker) for non diabetic patients in interventional group 4.