IRCT2014062412789N5 IRCT 2014-09-13 Vice Chancellor for Research, Kurdistan University of Medical Sciences Ketamine efficacy on succinylcholine induced myalgia in outpatient surgeries Comparison the effect of Ketamin and placebo on succinylcholine induced Myalgia in candidates of outpatient surgeries - A Double Blind Randomized Controlled Trial 2013-11-22 anticipated 144 Complete https://irct.ir/trial/12794 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: With randomized block method in categories of four persons, patients were divided into two intervention and control groups. Injection was performed by an anesthesiologist who was informed about patients grouping. Myalgia was measured by an observer who was not aware about injected drug (ketamine or distilled water). Researcher also was not aware of patients grouping and patients did not know to which group (control or intervention) they are located. Monitoring team was aware of patients grouping. 3 Myalgia. Intervention 1: ketamine 0.5 Mg per Kg (By adding distilled water the volume was reached to 5 mm) was injected to patients in the intervention group. Then 1.5 mic per kg fentanyl was injected as pre-medication prior to induction of anesthesia and 3 minutes after administration of ketamine and fentanyl, induction of anesthesia using propofol 2 to 2.5 mg per kg was performed. After the disappearance of the corneal reflex succinylcholine 1.5 mg/kg was used for muscle relaxation. Intervention 2: In the intervention group 5 mm distilled water was injected. Then 1.5 mic per kg fentanyl was injected as pre-medication prior to induction of anesthesia and 3 minutes after administration of ketamine and fentanyl, induction of anesthesia using propofol 2 to 2.5 mg per kg was performed. After the disappearance of the corneal reflex succinylcholine 1.5 mg/kg was used for muscle relaxation.