IRCT201108171760N14 IRCT 2012-07-14 Vice Chancellor for Research and Technology, Babol University of Medical Sciences Effect of the Folic Acid and Vitamin B12 Supplements with Metformin on the Plasma Homocysteine Levels in Women with Polycystic Ovary Syndrome Effect of the Folic Acid and Vitamin B12 Supplements with Metformin on the Plasma Homocysteine Levels in Women with Polycystic Ovary Syndrome 2011-08-23 anticipated 150 Complete https://irct.ir/trial/1278 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Polycystic ovary syndrome. Intervention 1: Control group(1): Treated with metformin tablets (500 mg twice daily).Treated for 6 months. Intervention 2: Intervention: group(2):Treated with metformin tablets (500 mg twice daily) with supplements of vitamin B12 (1000 micrograms weekly injections), will be treated for 6 months. Intervention 3: Intervention: group(3):Treated with metformin tablets (500 mg twice daily) with folic acid supplements (1 mg daily), will be treated for 6 months.