IRCT2013022412588N1 IRCT 2013-03-18 Vise-Challenger of research of Tehran University of Medical Sciences Effect of nebulized magnesium sulfate in management of acute asthma attack Comparison of nebulized magnesium sulfate with placebo in the management of patients with moderate to severe acute asthma attack presented to the emergency department 2013-03-05 anticipated 50 Complete https://irct.ir/trial/12631 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A asthma. Intervention 1: In addition of standard treatment of asthma (50 mg oral prednisolone, 2.5 mg nebulized salbutamol, 0.5 mg nebulized atrovent ), case group will receive 500 mg of nebulized magnesium sulfate (1cc of sulfate 50%) each 20 minutes up to 1 hour. Intervention 2: standard treatment of asthma (50 mg oral prednisolone, 2.5 mg nebulized salbutamol, 0.5 mg nebulized atrovent ) but instead of nebulized magnesium sulfate will bli receive 1cc of nebulized normal saline each 20 minutes up to 1 hour as placebo.