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IRCT2014032512494N1 IRCT 2014-03-25 Vice chancellor for research, Shahid Beheshti University of Medical Science Comparison between conventional blind embryo transfer and embryo transfer based on previously measured uterine length Comparison between the effect of conventional embryo transfer and embryo transfer based on previously measured uterine length on pregnancy and implantation rates in fresh ART cycles in IVF ward of Taleghani Hospital 2009-12-31 anticipated 160 Complete https://irct.ir/trial/12572 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2 Infertility. Intervention 1: In intervention group: The type of stimulatory cycle (Agonist or Antagonist) were selected based on the age of woman and other factores. (agonist;Superfact: mination Hoechst, Frankfurt, Germany)antagonist;cetrotide,EMDSerono,inc).Ovarian stimulation was done using r-FSH (GonalF;Serono,Laboratories.Ltd,Geneva,Switzerland),Merional or Fostimon ( IBSA,Switzerland), single or in combination. When the leading follicles reachd 17-18mm in diameter HCG 10,000 unit (IBSA,Switzerland) was administered. The uterine length was measured, on the day of HCG administration, by recording the distance from the external os to the uterine fundus using vaginal sonography. Oocyte retrieval was performed 34-36 hours later. The day of embryo transfer is determined by convenience after 48-72 h. Procedure: All women are placed in the lithotomy position (with an empty bladder) and a sterile metal speculum is placed to expose the cervix. The cervical mucus is cleaned using ringer solution and then the external os is washed with media (ham’s F 10 liquid).In all cases a Cook catheter ( COOK medical USA ) are used. First the outer catheter and then the inner catheter that load the embryos is placed. The site of embryo deposition in the uterus is determined based on uterine length measurement by vaginal ultrasound at the day of HCG and embryo deposition is done in depth of 1-1.5 cm from the end of uterine cavity . Intervention 2: In control group: The type of stimulatory cycle (Agonist or Antagonist) are selected based on the age of woman and other factores. (agonist;Superfact: mination Hoechst, Frankfurt, Germany)antagonist;cetrotide,EMDSerono,inc).Ovarian stimulation is done using r-FSH (GonalF;Serono,Laboratories.Ltd,Geneva,Switzerland),Merional or Fostimon ( IBSA,Switzerland), single or in combination. When the leading follicles reachd 17-18mm in diameter HCG 10,000 unit (IBSA,Switzerland) is administered. The uterine length is measured, on the day of HCG administration, by recording the distance from the external os to the uterine fundus using vaginal sonography. Oocyte retrieval is performed 34-36 hours later. The day of embryo transfer is determined by convenience ,after 48 or 72h. Procedure: All women are placed in the lithotomy position (with an empty bladder) and a sterile metal speculum is placed to expose the cervix. The cervical mucus is cleaned using ringer solution and then the external os is washed with media (ham’s F 10 liquid).In all cases a Cook catheter ( COOK medical USA ) are used. First the outer catheter and then the inner catheter that loaded the embryos is placed. In this group embryos are blindly deposited at the middle portion of the uterine cavity approximately at 5-6cm distance from the external os and based on physician experience.
public Dr.Nasrin Saharkhiz
Taleghani Hospital, IVF ward, Velenjak, Shahid Chamran higway, Tehran
Tehran Iran (Islamic Republic of) 1985711151 +98 21 2243 2558 saharkhiz1377@yahoo.com Infertility & Reproductive Health Research Centre - Shahid Beheshti of Medical Science scientific Dr. Nasrin Saharkhiz
Taleghani Hospital, IVF ward, Velenjak, Shahid Chamran highway, Tehran
Tehran Iran (Islamic Republic of) 1985711151 +98 21 2243 2558 saharkhiz1377@yahoo.com Infertility & Reproductive Health Research Centre - Shahid Beheshti of Medical Science Iran (Islamic Republic of) Inclusion criteria: All the patients who underwent ICSI in this period of time in our center that reached the embryo transfer step, were enrolled in the study. Exclusion criteria : Egg donation cycles; embryo donation cycles; frozen embryo transfers were excluded. 18 years 45 years Female Not have Not have Other Treatment - Drugs In intervention group: The type of stimulatory cycle (Agonist or Antagonist) were selected based on the age of woman and other factores. (agonist;Superfact: mination Hoechst, Frankfurt, Germany)antagonist;cetrotide,EMDSerono,inc).Ovarian stimulation was done using r-FSH (GonalF;Serono,Laboratories.Ltd,Geneva,Switzerland),Merional or Fostimon ( IBSA,Switzerland), single or in combination. When the leading follicles reachd 17-18mm in diameter HCG 10,000 unit (IBSA,Switzerland) was administered. The uterine length was measured, on the day of HCG administration, by recording the distance from the external os to the uterine fundus using vaginal sonography. Oocyte retrieval was performed 34-36 hours later. The day of embryo transfer is determined by convenience after 48-72 h. Procedure: All women are placed in the lithotomy position (with an empty bladder) and a sterile metal speculum is placed to expose the cervix. The cervical mucus is cleaned using ringer solution and then the external os is washed with media (ham’s F 10 liquid).In all cases a Cook catheter ( COOK medical USA ) are used. First the outer catheter and then the inner catheter that load the embryos is placed. The site of embryo deposition in the uterus is determined based on uterine length measurement by vaginal ultrasound at the day of HCG and embryo deposition is done in depth of 1-1.5 cm from the end of uterine cavity . In control group: The type of stimulatory cycle (Agonist or Antagonist) are selected based on the age of woman and other factores. (agonist;Superfact: mination Hoechst, Frankfurt, Germany)antagonist;cetrotide,EMDSerono,inc).Ovarian stimulation is done using r-FSH (GonalF;Serono,Laboratories.Ltd,Geneva,Switzerland),Merional or Fostimon ( IBSA,Switzerland), single or in combination. When the leading follicles reachd 17-18mm in diameter HCG 10,000 unit (IBSA,Switzerland) is administered. The uterine length is measured, on the day of HCG administration, by recording the distance from the external os to the uterine fundus using vaginal sonography. Oocyte retrieval is performed 34-36 hours later. The day of embryo transfer is determined by convenience ,after 48 or 72h. Procedure: All women are placed in the lithotomy position (with an empty bladder) and a sterile metal speculum is placed to expose the cervix. The cervical mucus is cleaned using ringer solution and then the external os is washed with media (ham’s F 10 liquid).In all cases a Cook catheter ( COOK medical USA ) are used. First the outer catheter and then the inner catheter that loaded the embryos is placed. In this group embryos are blindly deposited at the middle portion of the uterine cavity approximately at 5-6cm distance from the external os and based on physician experience. Chemical pregnancy. Timepoint: 2wks after embryo transfer. Method of measurement: Serum B-HCG. Clinical pregnancy. Timepoint: 4 weeks after embryo transfer. Method of measurement: Vaginal sonography. Ongoing pregnancy. Timepoint: 10 weeks after embryo transfer. Method of measurement: Vaginal sonography. Implantation rate. Timepoint: End of the study. Method of measurement: Number of gestational sacs at vaginal sonography divided by total number of transfered embryos. Abortion rate. Timepoint: First trimester. Method of measurement: Clinical sign and vaginal ultrasound. Ectopic pregnancy rate. Timepoint: First trimester. Method of measurement: Clinical sign and vaginal ultrasound. not have not have Vice chancellor for research, Shahid Beheshti University of Medical Science Approved 2012-09-26 Infertility & Reproductive Health Research Center Ethics committee of Shahid Beheshti University of Taleghani Hospital 3rd floor-Velenjak-Shahid Chamran highway-Tehran Tehran Iran (Islamic Republic of)