IRCT2015111812460N8 IRCT 2016-01-31 Educational vice chancellor of Tehran University of Medical Sciences Development and evaluation of an educational - Supportive intervention to improve quality of life in adult patients with thalassemia major Comparing effect of receiving and not receiving an educational - Supportive intervention on quality of life in adult patients with thalassemia major 2016-01-01 anticipated 136 Complete https://irct.ir/trial/12542 interventional Randomization: Not randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive. N/A Major Thalassemia. Intervention 1: In the intervention group, the following measures will be done: holding educational interventions in order to improve quality of life and lifestyle. Type of intervention, intervention of the target groups, educational content, teaching methods, number and timing of training classes, will be determined according to the analysis of the results of the pretest. Intervention 2: There would be no intervention in control group, therefore, the control members will receive routine educational programs from respective medical institutions including: visits by doctor of clinic, vaccinations, blood transfusion, nursing care before, during and after blood transfusion, educating how to use Desferal pump, educating how to iron chelation.