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IRCT201308041743N11 IRCT 2013-11-05 Research center for behavioral disorders and substance abuse, Hamadan University of Medical Science Efficacy of Repetitive Transcranial Magnetic Stimulation in Treating Refractory Obsessive Compulsive Disorder Efficacy of Repetitive Transcranial Magnetic Stimulation in Treating Refractory Obsessive Compulsive Disorder 2013-02-19 anticipated 21 Complete https://irct.ir/trial/1250 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Crossover, Purpose: Treatment. N/A refractory obsessive compulsive disorder. Device: repetitive magnetic stimulation(rTMS) 750 total pulse stimulation at 20 Hz will be delivered with 25 train of 1.5 second duration at 100% of threshold. Bilaterally(right and left) Sham stimulation with coil angled 45-90 degree will applied at the site exactly like rTMS stimulation in total 25 minute.(right and left).This is like true stimulation but have no therapeutic effect.
public Mehran Shaygan Fard
Farshchian Hospital
Hamadan Iran (Islamic Republic of) 65168-4-8741 +98 81 1827 4192 mshayganfard@yahoo.com Research center for behavioral disorders and substance abuse, Hamadan University of Medical Science scientific Dr. Mohammad Haghighi
Farshchian Hospital
Hamadan Iran (Islamic Republic of) 65168-4-8741 +98 81 1827 4192 haghighi@umsha.ac.ir Research center for behavioral disorders and substance abuse, Hamadan university of medical sciences Iran (Islamic Republic of) Inclusion Criteria: •voluntary and competent to consent based on their ability to provide a spontaneous narrative description of the key elements of the study •have a Structured Clinical Interview for DSM-IV (SCID) confirmed diagnosis of OCD •are between the ages of 18 and 65 •have failed to achieve a clinical response, or did not tolerate, at least 3 separate antidepressant trials of sufficient dose (included clomipramine) and CBT for at least 10 weeks •have a score of greater than or equal to 17 on the Y-BOCS. A careful medical and neurological history will be taken to ensure that subjects have no unstable conditions that would preclude them from entering into the study. This history will focus on conditions such as seizures, neurologic, other medical problems and presence of metal implants Exclusion Criteria: •have a history of DSM-IV substance dependence in the last 6 months, and have DSM-IV substance abuse in the last month •have a concomitant major unstable medical or neurologic illness or have had a history of seizures •acutely suicidal •are pregnant •have metal implants. With respect to concomitant medications, patients will be excluded if they are currently (or in the last 4 weeks) taking: (a) more than lorazepam 2 mg daily (or equivalent), (b) monoamine oxidase inhibitors, (c) and/or bupropion due to its associated increased risk for seizures. 18 years 65 years Both F42.2 Mixed obsessional thoughts and acts Other Device: repetitive magnetic stimulation(rTMS) 750 total pulse stimulation at 20 Hz will be delivered with 25 train of 1.5 second duration at 100% of threshold. Bilaterally(right and left) Sham stimulation with coil angled 45-90 degree will applied at the site exactly like rTMS stimulation in total 25 minute.(right and left).This is like true stimulation but have no therapeutic effect Improvement rate of refractory OCD. Timepoint: after 10th, 20th sessions of rTMS or sham. Method of measurement: CGI و YBOCS. Research center for behavioral disorders and substance abuse, Hamadan University of Medical Science Approved 2013-07-25 Hamadan University of Medical Sciences Shahid Fahmideh Street Hamadan Iran (Islamic Republic of)