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IRCT2013020512369N1 IRCT 2016-06-19 Vice chancellor for research, Isfahan University of Medical Sciences The effect of Nitrous Oxide in comparison to Oxygen combined with Fentanyl on the staying time and pain reduction in renal colic patients at Emergency room The effect of Nitrous Oxide in comparison to Oxygen combined with Fentanyl on the staying time and pain reduction in renal colic patients at Emergency room 2016-03-20 anticipated 120 Complete https://irct.ir/trial/12433 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive. 2-3 renal colic. Intervention 1: At the beginning 50 microgram (µg) fentanyl was infused for all of the patients. First group was received mask of oxygen. Patients were able to remove the mask if their pain was relief. If the pain was not relief after 30 minutes, 50 µg fentanyl was infused again. Finally, if the patient was still suffering from pain, another usual pain relieving agent such as Ketorolac and Ketamine was used to decrease the severity of patient's pain. Intervention 2: At the beginning 50 microgram (µg) fentanyl was infused for all of the patients. First group was received mask of oxygen. Patients were able to remove the mask if their pain was relief. If the pain was not relief after 30 minutes, 50 µg fentanyl was infused again. Finally, if the patient was still suffering from pain, another usual pain relieving agent such as Ketorolac and Ketamine was used to decrease the severity of patient's pain.
public Omid Ahmadi
Department of Emergency Medicine, Alzahra hospital, Sofeh street, Isfahan, Iran
Isfahan Iran (Islamic Republic of) +98 31 3261 3464 omid.ep@med.mui.ac.ir Department of Emergency Medicine, Isfahan University of Medical Sciences scientific Omid Ahmadi
Department of Emergency Medicine, Alzahra hospital, Sofe street, Isfahan, Iran
Isfahan Iran (Islamic Republic of) +98 31 3668 5555 omid.ep@med.mui.ac.ir Department of Emergency Medicine, Isfahan University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria were as follows: Age>18 yr; Definite diagnosis of renal colic; Stable hemodynamic (PR=60-100، SBP>100، SPO2>90%،RR=8-22); lack of analgesics usage during last 24 hour; absence of these conditions in patients history: asthma, COPD, intestinal obstruction, hypertension, heart failure, history of previous surgery on kidney and urinary tract, peptic ulcer, GI bleeding, previous history of allergy to fentanyl or other analgesic agents, loss of consciousness, head or chest trauma, pneumocephalus, pneumothorax, drug abuse, abdominal tenderness, rebound tenderness or guarding, retard menstruation; Fill the Informed consent form Patients were excluded if: The patient hemodynamic becomes unstable during the process of hospitalization; Hypersensitivity reaction to analgesic drugs occurred; The diagnosis were changed during the further investigations 18 years no limit Both N23 Unspecified renal colic Treatment - Drugs Treatment - Drugs At the beginning 50 microgram (µg) fentanyl was infused for all of the patients. First group was received mask of oxygen. Patients were able to remove the mask if their pain was relief. If the pain was not relief after 30 minutes, 50 µg fentanyl was infused again. Finally, if the patient was still suffering from pain, another usual pain relieving agent such as Ketorolac and Ketamine was used to decrease the severity of patient's pain. At the beginning 50 microgram (µg) fentanyl was infused for all of the patients. First group was received mask of oxygen. Patients were able to remove the mask if their pain was relief. If the pain was not relief after 30 minutes, 50 µg fentanyl was infused again. Finally, if the patient was still suffering from pain, another usual pain relieving agent such as Ketorolac and Ketamine was used to decrease the severity of patient's pain. Duration of hospitalization. Timepoint: at the end of the intervention. Method of measurement: minutes by timer. Severity of pain. Timepoint: before and 3-, 5-, 10- and 30-minute after the intervention. Method of measurement: visual analogue scale. Vice chancellor for research, Isfahan University of Medical Sciences Approved 2016-02-03 Ethics committee of Isfahan University of Medical Sciences Hezar jirib street, Isfahan Uuniversity of Medical Science Isfahan Iran (Islamic Republic of)