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IRCT2013072412146N2 IRCT 2013-08-03 Vice chancellor for research, Tabriz University of Medical Sciences Combination of trauma and drug as a treatment for implantation failure The effect of endometrial local injury and GnRH agonist on pregnancy rate in patients with recurrent implantation failure 2013-01-10 anticipated 76 Complete https://irct.ir/trial/12268 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Female infertility. Intervention 1: For intervention group: A pipelle biopsy to cause endometrial trauma in the day 19th will be performed and superfact 500µg subcutaneously in the day 21st of the menstrual period will be administered and then routine in vitro fertilization will be performed. Intervention 2: For control group superfact 500µg subcutaneously will be administered in day 21st of the menstrual period and then routine in vitro fertilization will be performed.
public Arefe Fakour
Alzahra Hodpital, Baghshomal Sq.
Tabriz Iran (Islamic Republic of) +98 41 1335 7310 a.Fakour@yahoo.com Tabriz University of Medical Sciences scientific Laya Farzadi
Alzahra Hospital, Baghshomal Sq.
Tabriz Iran (Islamic Republic of) +98 41 1335 7310 farzadl@tbzmed.ac.ir Tabriz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: patients with two or more implantation failure in IVF; to be 18 to 40 years old; not to suffer from any systemic disease such as diabetes, hypertension, etc.) Exclusion criterion: occurrence of intolerable adverse effects. 18 years 40 years Female N97 Female infertility Treatment - Other Treatment - Drugs For intervention group: A pipelle biopsy to cause endometrial trauma in the day 19th will be performed and superfact 500µg subcutaneously in the day 21st of the menstrual period will be administered and then routine in vitro fertilization will be performed. For control group superfact 500µg subcutaneously will be administered in day 21st of the menstrual period and then routine in vitro fertilization will be performed. Pregnancy. Timepoint: 10 days after in vitro fertilization. Method of measurement: Sending blood sample to laboratory to measure Beta HCG level. Vice chancellor for research, Tabriz University of Medical Sciences Approved 2013-01-08 Ethics Committee of Tabriz University of Medical Sciences Tabriz University of Medical Sciences, Daneshgah Sq. Tabriz Iran (Islamic Republic of)