IRCT2012122511885N1 IRCT 2013-07-01 Vice chancellor for research, Mazandaran University of Medical Sciences Opium tincture and methadone syrup effectiveness for management of opium withdrawal Comparison of the effectiveness of opium tincture and methadone syrup for management of acute opium withdrawal. 2012-11-08 anticipated 74 Complete https://irct.ir/trial/12061 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: The block randomization method is used . Since the taste ,appearance and odor of both drugs is equalized patients and rater are blind to them. 3 opium Withdrawal. Intervention 1: In methadone group, regarding to a severity of dependence )Based on Addiction Severity Index( mild, moderate, severe, methadone syrup (Made by Exir Company) 15, 30 and 45 mg may be administered, respectively. Drug was continued in two divided doses for 5 days with a constant dose and then tapered 20% per day. At the end of Tenth Day drug was discontinued. Intervention 2: In Tincture of Opium group, regarding to a severity of dependence )Based on Addiction Severity Index( mild, moderate, severe, Tincture of Opium (Made by Daroupakhsh Company) 45, 90 and 135 mg may be administered, respectively. Drug was continued in two divided doses for 5 days with a constant dose and then tapered 20% per day. At the end of Tenth Day drug was discontinued.