]>
IRCT2014012611873N2 IRCT 2014-03-17 Ahvaz JondyShapour University of Medical Sciences Efficacy of glucocorticoids and cyclophosphamide in the treatment of paraquat poisoning Effect of pulse therapy with glucocorticoids and cyclophosphamide in patients with paraquat poisoning 2013-01-20 anticipated 46 Complete https://irct.ir/trial/12057 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A poisoning with the pesticide paraquat. Intervention 1: ent emergency hemodialysis in the fastest time possible. After the dialysis, the intervention group received 15 mg/Kg CP for two days and 1g MP for three days. Each drug infused in 200 cc dextrose saline 5 % during two hours. Intervention 2: After the initial measures, including gastric lavage and administration of activated charcoal and two charcoal dialysis. The control group consisted of normal saline placebo is used, 200 cc given intravenously over two hours to three days is prescribed.
public Dr Ahmad Ghorbani
Esfand St, Golestan Blv.
Ahvaz Iran (Islamic Republic of) +98 61 1333 5935 ahmadghorbanidr@yahoo.com Ahvaz Jondishapour University of Medical Sciences scientific Dr Amir Mandegar
Esfand St, Golestan Blv.
Ahvaz Iran (Islamic Republic of) +98 61 1374 3030 mandegaramir@gmail.com Ahvaz Jondishapour University of Medical Sciences Iran (Islamic Republic of) Inclusion Criteria: approved the pesticide paraquat during the last 24; moderate to severe poisoning with this herbicide The exclusion criteria: In addition to any other pesticide paraquat; the underlying liver disease - kidney - lung; The incidence of treatment-related complications during interventional treatment 15 years 40 years Both Treatment - Drugs Placebo ent emergency hemodialysis in the fastest time possible. After the dialysis, the intervention group received 15 mg/Kg CP for two days and 1g MP for three days. Each drug infused in 200 cc dextrose saline 5 % during two hours. After the initial measures, including gastric lavage and administration of activated charcoal and two charcoal dialysis. The control group consisted of normal saline placebo is used, 200 cc given intravenously over two hours to three days is prescribed. Kidney failure. Timepoint: Daily during treatment. Method of measurement: BUN & Cr..Cr: 1.4 mg/dl (i.e., mean normal value + 2 standard deviations). Mortality. Timepoint: Constantly during treatment. Method of measurement: Observation. Hepatitis (liver failure). Timepoint: Daily during treatment. Method of measurement: (ST) and(ALT) values were > 70 U/L (normal valueis < 35 U/L) or when total bilirubin was > 3.0 mg/dl (normal valueis < 1.4 mg/dl). Hypoxia. Timepoint: Daily during treatment. Method of measurement: PaO2 < 80 mm Hg at roomair. Ahvaz JondyShapour University of Medical Sciences Approved 2012-09-22 Ahvaz Jondishapour University of Medical Sciences Esfand St, Golestan Blv. Ahvaz Iran (Islamic Republic of)