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IRCT2013070411853N2 IRCT 2013-09-08 Shiraz University of Medical Sciences Effect of Vitamin C in Kidney Function After Transplantation Early Outcome of Kidney Function After Transplantation when Use Vitamin C in Decease Donors. 2013-07-06 anticipated 180 Complete https://irct.ir/trial/12033 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. N/A kidney transplantation. Intervention 1: In this study, we investigated the protective effects of Ascorbic acid(1000 mg I.V. in intervention group) in renal cell damage due to ischemic-re perfusion injury, by measuring NGAL level in brain death patients in ICU, and follow function of these kidneys after transplant in operating room and in ward by repeated measuring of this bio marker. Intervention 2: In control group 10cc N/S ( Equivalent with 2 Ampul of Vitamin C) is injected within 6 hours.
public Mohammad Bagher Khosravi
Nemazi Hospital
Shiraz Iran (Islamic Republic of) +98 71 1233 7636 khosravim@sums.ac.ir Shiraz University of Medical Sciences scientific Mohammad Firoozifar
Nemazi Hospital
Shiraz Iran (Islamic Republic of) +98 71 1233 7636 firoozifar@sums.ac.ir or m.firoozifar@gmail.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Brain Death Patients in range of 20-65 years old ; Patients with History of kidney problems under Dialysis in list of Transplantation; Patients with kidney problems with Age between 20-60 years Exclusion criteria:Brain Death Patients with history of cardiac problems; Brain Death Patients with Cr>1.5 mg/dl; Brain Death Patients with Age>65 year; Patients with kidney problems with Age>65 years old no limit 65 years Both N17.0 Acute renal failure with tubular necrosis Prevention Prevention In this study, we investigated the protective effects of Ascorbic acid(1000 mg I.V. in intervention group) in renal cell damage due to ischemic-re perfusion injury, by measuring NGAL level in brain death patients in ICU, and follow function of these kidneys after transplant in operating room and in ward by repeated measuring of this bio marker In control group 10cc N/S ( Equivalent with 2 Ampul of Vitamin C) is injected within 6 hours. NGAL (Neutrophil gelatinase- associated lipocalin). Timepoint: baseline values of NGAL is measured in all brain death patients in ICU prior to starting ascorbic acid and then repeat, before aortic clamping in donors and 4 and 24 hours after renal artery declamping in recipients. Method of measurement: By Keith. BUN. Timepoint: for 5 days post operation. Method of measurement: Lab. Cr. Timepoint: for 5 days post operation. Method of measurement: Lab. Frequency of dialysis. Timepoint: for 5 days post operation. Method of measurement: measured in ward. Total diuretic drugs. Timepoint: for 5 days post operation. Method of measurement: measured in ward. Shiraz University of Medical Sciences Approved 2013-04-25 Shiraz University of Medical Sciences Zand Street Shiraz Iran (Islamic Republic of)