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IRCT2012121911822N1 IRCT 2013-04-04 Vice chancellor of Research and Technology, Hamadan University of Medical Science Comparison of intravenous infusion of propofol and sodium valproate on alleviation of acute migraine ASA: American Society of Anesthesiologists; NRS: Numerical Rating scale Comparison of intravenous infusion of propofol and sodium valproate on alleviation of acute migraine 2013-04-04 anticipated 60 Complete https://irct.ir/trial/12018 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Migraine Headache. Intervention 1: َA single dose of 200 mg propofol mixed with 500 ml normal saline within 45 minute. Intervention 2: A single dose 500 mg sodium valproate mixed with 500 ml normal saline within 45 minute.
public Behrooz Karkhanei
Medicine Faculty, Hamadan University of Medical Sciences, Shaheed Fahmideh
Hamadan Iran (Islamic Republic of) +98 81 1838 0574 karkhanei@umsha.ac.ir Hamadan University of Medical Sciences scientific Behrooz Karkhanei
Medicine Faculty, Hamadan University of Medical Sciences, Shaheed Fahmideh
Hamadan Iran (Islamic Republic of) +98 81 1838 0574 karkhanei@umsha.ac.ir Hamadan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Acute migraine attack; 20 to 50 years; ASA≤II Exclusion criteria: Patient refuse; Allergy to propofol or sodium valproate; Allergy to egg or soya 20 years 50 years Both G43 Migraine Treatment - Drugs Treatment - Drugs َA single dose of 200 mg propofol mixed with 500 ml normal saline within 45 minute. A single dose 500 mg sodium valproate mixed with 500 ml normal saline within 45 minute. Headache severity. Timepoint: Before administration of drugs and each 15 min during drug infusion and each 30 min for two hours. Also, in patient with reduced severity of pain we will assist pain severity for next 24 and 48 hours. Method of measurement: Numerical Rating Scale (NRS), 0 for without pain and 10 for worst pain. Any side effect such as allergy. Timepoint: Each 15 min during drug infusion and each 30 min for two hours. Also, in patient with reduced pain for next 24 and 48 hours through the telephone. Method of measurement: Ask from patient according to Questionnaire. Vice chancellor of Research and Technology, Hamadan University of Medical Science Approved 2013-02-24 Local Human Subject Review Board Hamadan University Of Medical Sciences, Shaheed Famideh Street Hamadan Iran (Islamic Republic of)