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IRCT2012121711785N1 IRCT 2013-02-01 Shiraz University of Medical Sciences The effect of coenzyme Q10 supplementation on the management of type 2 diabetes The effect of coenzyme Q10 supplementation on glycemic control, inflammatory markers, lipid profile, oxidative stress and blood pressure in type 2 diabetic patients: a placebo-controlled trial 2012-07-22 anticipated 54 Complete https://irct.ir/trial/11994 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Other design features: Since the samples are selected by the researcher, this is a single blind study. 2 Type 2 diabetes mellitus. Intervention 1: coenzyme Q10 capsule, 100 mg, twice per day, for eight weeks, edible. Health Burst brand. Intervention 2: Cellulose acetate, 100 mg, two capsules per day, for eight weeks, edible, made in Shiraz School of Pharmacy.
public Mahsa Moazen
Nutrition Department, School of Health and Nutrition, Shiraz University of Medical Sciences
Shiraz Iran (Islamic Republic of) +98 71 1725 1001 moazzen@sums.ac.ir Shiraz University of Medical Sciences scientific Dr. Zohreh Mazloom
Nutrition department, School of Health and Nutrition, Shiraz University of Medical Sciences
Shiraz Iran (Islamic Republic of) +98 71 1725 1001 zohreh.mazloom@gmail.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: Type 2 diabetic patients, with body mass index 20-30. Exclusion criteria: Patients with any chronic renal, hepatic and gastrointestinal disorders, using anticoagulants, lipid lowering medications and β-blockers, consumption of vitamin-mineral supplements, following specific diets and smokers. In the case of decreasing or increasing the blood glucose lowering medications the patient will be excluded from the study. 35 years 60 years Both E11 Non-insulin-dependent diabetes mellitus Other Placebo coenzyme Q10 capsule, 100 mg, twice per day, for eight weeks, edible. Health Burst brand Cellulose acetate, 100 mg, two capsules per day, for eight weeks, edible, made in Shiraz School of Pharmacy Fasting blood sugar. Timepoint: at the beginning of intervention, at the end of intervention. Method of measurement: BT 1500 autoanalyzer, unit: mg/dl. Hemoglobin A1c. Timepoint: at the beginning of intervention, at the end of intervention. Method of measurement: HPLC method, will be reported as percentage. Insulin. Timepoint: at the beginning of intervention, at the end of intervention. Method of measurement: ELISA method, unit: μIU/ml. Insulin resistance. Timepoint: at the beginning of intervention, at the end of intervention. Method of measurement: according to the formula. High-sensitivity C-reactive protein. Timepoint: at the beginning of intervention, at the end of intervention. Method of measurement: ELISA method, unit: ng/ml. Adiponectin. Timepoint: at the beginning of intervention, at the end of intervention. Method of measurement: ELISA method, unit: μg/ml. Triglyceride. Timepoint: at the beginning of intervention, at the end of intervention. Method of measurement: BT-1500 autoanalyzer, unit: mg/dl. Total cholesterol. Timepoint: at the beginning of intervention, at the end of intervention. Method of measurement: BT-1500 autoanalyzer, unit: mg/dl. LDL- cholesterol. Timepoint: at the beginning of intervention, at the end of intervention. Method of measurement: BT-1500 autoanalyzer, unit: mg/dl. HDL- cholesterol. Timepoint: at the beginning of intervention, at the end of intervention. Method of measurement: BT-1500 autoanalyzer, unit: mg/dl. Malondialdehyde. Timepoint: at the beginning of intervention, at the end of intervention. Method of measurement: spectrophotometry, unit: μmol/l. Blood pressure. Timepoint: at the beginning of intervention, at the end of intervention. Method of measurement: mercury sphygmomanometer, unit: mmHg. Hip circumference. Timepoint: at the beginning of intervention, at the end of intervention. Method of measurement: measuring with a tape measure, unit: centimeter. Weight. Timepoint: at the beginning of intervention, at the end of intervention. Method of measurement: analog scale, unit: kg. Body Mass Index. Timepoint: at the beginning of intervention, at the end of intervention. Method of measurement: according to the formula, unit: kg/m2. Waist circumference. Timepoint: at the beginning of intervention, at the end of intervention. Method of measurement: measuring with a tape measure, unit: centimeter. Shiraz University of Medical Sciences Approved 2012-07-15 Ethics committee of Shiraz University of Medical Sciences Zand St. Shiraz Iran (Islamic Republic of)