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IRCT20121216011763N23 IRCT 2018-01-16 Vice chancellor for research, University of Medical Sciences of Esfahan Effect of Zinc supplementation on symptoms of migraine Effect of zinc supplementation on symptoms among patients with migraine in comparison with placebo 2016-02-01 anticipated 80 Complete https://irct.ir/trial/11936 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In present study, simple randomization method will be used. The randomization unit is individually and we will use the random number table method for random sequences. A random numbered table is a collection of numbers that are without a specific pattern, completely random and as table. The next step is allocation concealment and will use sequentially numbered, sealed, opaque envelopes. Then, based on the sample size, number of envelopes with aluminum surface are provided and each random sequence created on a card and the cards are inserted into the envelopes, respectively. At the time of registration for the participants, according to eligible participants, one of the envelopes is opened and the allocated group for participants is revealed, Blinding description: Supplementation zinc and placebo will be packed in capsules that are identical in outward. 3 migraine. Intervention 1: Intervention group: Supplementation of zinc sulfate (220 mg including 50 mg of elemental zinc, Alhavi Company), every day 1 supplement, 8 weeks. Intervention 2: control group: placebo (made at the School of Pharmacy, Isfahan University of Medical Sciences ), every day 1 supplement, 8 weeks. Undecided - It is not yet known if there will be a plan to make this available
public Hedieh Ahmadi
Isfahan University of Medical Sciences, Hezar Jarib Ave
Isfahan Iran (Islamic Republic of) 8135798111 +98 31 3792 3171 hedieh_ahmadi85@yahoo.com Esfahan University of Medical Sciences scientific Dr.Gholamreza Askari
Isfahan University of Medical Sciences, Hezar Jarib Ave
Isfahan Iran (Islamic Republic of) 8135798111 +98 31337923171 askari@mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) aged 20-60 years; confirmation of migraine by neurologist; desire to participate in present study; do not use of oral contraceptive pill, lack of tension headaches. 20 years 60 years Both having chronic medical diseases; use of supplements containing Zn, vitamin E, vitamin C, Selenium and Beta-carotene G43.9 Migraine, unspecified Treatment - Drugs Placebo Intervention group: Supplementation of zinc sulfate (220 mg including 50 mg of elemental zinc, Alhavi Company), every day 1 supplement, 8 weeks control group: placebo (made at the School of Pharmacy, Isfahan University of Medical Sciences ), every day 1 supplement, 8 weeks Migraine symptoms ( severity, frequency and average duration of migraine attacks). Timepoint: At first and end of intervention. Method of measurement: Questionaire. C-reactive protein (CRP). Timepoint: At first and end of intervention. Method of measurement: Laboratory analysis ( blood test). Migraine Disability Assessment. Timepoint: At first and end of intervention. Method of measurement: Questionaire. Vice chancellor for research, University of Medical Sciences of Esfahan Approved 2015-12-22 Ethical Committee of Isfahan University of Medical Sciences Isfahan University of Medical Sciences, Hezar Jerib Avenue Isfahan Isfehan Iran (Islamic Republic of)