IRCT2012120811689N1 IRCT 2013-02-12 Vice chancellor for Research, Tabriz University of Medical Sciences The effects of nigella sativa oil on rheumatoid arthritis treatment A placebo- controlled clinical trial to determine the effects of nigella sativa oil extract on selected immune cell markers and oxidative stress in female patients with rheumatoid arthritis 2013-04-09 anticipated 50 Complete https://irct.ir/trial/11856 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: In the present study, patients' awareness about their study group may act as a confounder variable on some of outcome measures in particular disease activity scoring. Therefore, the study will be single blinded and all the participants will receive capsules with identical shape, size, and color. 2 Rheumatoid arthritis. Intervention 1: The control group will receive two soft gel capsules containing 500 milligram paraffin as placebo every day for eight consecutive weeks. The placebo preparation process will be conducted in Barij Essence Pharmaceutical Company under established standard protocols. All the patients will receive the placebos on a weekly base and will be monitored for consumption continuation and any possible adverse effects by telephone interviews. Intervention 2: The case group will receive two soft gel capsules containing 500 milligram of nigella sativa oil extract every day for eight consecutive weeks. The extraction will be conducted by cold press method. Both the extraction and soft gel making process will be conducted in Barij Essence Pharmaceutical Company under established standard protocols. All the patients will receive the supplements on a weekly base and will be monitored for consumption continuation and any possible adverse effects by telephone interviews.