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IRCT2012102811294N1 IRCT 2013-01-16 Vice chancellor for research of Ahvaz Jondishapour University of Medical Sciences Evaluation the effect of intraoperative administration of magnesium sulfate on post operative pain of patients undergoing general anesthesia for inguinal hernioraphy Evaluation the effect of intraoperative administration of magnesium sulfate on post operative pain of patient undergoing general anesthesia for inguinal hernioraphy 2012-08-22 anticipated 30 Complete https://irct.ir/trial/11578 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2-3 Postoperative Pain. Intervention 1: infusion of magnesium sulphate 40 miligram per kilogram before induction and then 15 miligram per kilogram per hour infusion during the operation until the 20 min after the end of surgery. Intervention 2: Infusion of isotonic saline 100 mililitre before induction and then 100 mililitre per hour infusion during the operation until the 20 min after the end of surgery.
public Zeinab Alizadeh
Anesthesiology department, Emam Khomeini Hospital, 20 meter street
Ahvaz Iran (Islamic Republic of) +98 61 1222 0168 alizadeh.md6010@yahoo.com Ahvaz Jondishapour University of Medical Sciences scientific Zeinab Alizadeh
Anesthesiology department, Emam Khomeini Hospital, 20 meter street
Ahvaz Iran (Islamic Republic of) +98 61 1222 0168 alizadeh.md6010@yahoo.com Ahvaz Jondishapour University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: patients with ASA 1 or 2 ; the patients without history of drug abuse ; without sensitivity to magnesium , opioids and analgesics ; any hepatic, renal, cardiovascular, neuromascular or neurological disorder ; not to use calcium channel blockers Exclusion criteria: patients with preoperative hemodynamic instability ; preoperative respiratory distress; preoperative nausea and vomiting or any important adverse effects ; patients with magnesium infusion time less than one hour and more than 3 hours. 16 years 60 years Both R52.0 Acute pain Treatment - Drugs Treatment - Drugs infusion of magnesium sulphate 40 miligram per kilogram before induction and then 15 miligram per kilogram per hour infusion during the operation until the 20 min after the end of surgery Infusion of isotonic saline 100 mililitre before induction and then 100 mililitre per hour infusion during the operation until the 20 min after the end of surgery Pain score. Timepoint: 30 min , 2 hours, 6 hours, 12 hours, 24 hours after surgery. Method of measurement: Visual analogue scale. Meperidine consumption. Timepoint: in 24 hours after surgery. Method of measurement: milligramms. Incidence of adverse effects. Timepoint: In 24 hours after surgery. Method of measurement: Asking from patients. Vice chancellor for research of Ahvaz Jondishapour University of Medical Sciences Approved 2012-03-03 Ethics committee of Ahvaz Jondishapour University of Medical Sciences Jondishapour University Center, Golestan Boulevard Ahvaz Iran (Islamic Republic of)