IRCT2012101011067N1 IRCT 2013-05-12 Research Vice-Chancellor of Tabriz University of Medical Sciences comparison of three drugs to prevent hemodynamic response of orothracheal intubation Comparison Effect of Fentanyl, Sufentanil and Alfentanil on Hemodynamic at Rapid Sequence Intubation in the Emergency Department 2012-09-22 anticipated 90 Complete https://irct.ir/trial/11415 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomization was performed by providing the intubating physician, without informing him about the name of the medication, the different opiates labeled 1, 2 and 3 which were placed in the syringes containing similar amount of medication in each milliliter. When the patient entered the room, a ball was drawn from a bag containing 90 balls (30 balls labeled as 1, 30 as 2 and 30 as 3). Later, based on the number of the ball, the syringe with the similar number was used for the patient throughout the intubation. Neither the patient nor the physician was aware of the name of the opiate used in the intubation as the syringes were placed on the intubation tray by the project executor. 2 accidents. Intervention 1: Intervention group 1: 30 accidental patients with normal blood pressure that will require intubation with rapid sequence method, alfentanil, single dose intravenous administration 20 micrograms per kilogram (1 cc :500micrograms, Janssen Pharmaceutical Company, Beerse, Belgium) has been used for intubation. Intervention 2: Intervention group 1: 30 accidental patients with normal blood pressure that will require intubation with rapid sequence method, sufentanil, single dose intravenous administration 0.2 micrograms per kilogram (1 cc :5 micrograms, Mylan Pharmaceutical Company, Saint Priest, France) has been used for intubation. Intervention 3: Control group: 30 accidental patients with normal blood pressure that will require intubation with rapid sequence method, fentanyl, single dose intravenous administration 2 micrograms per kilogram (1 cc :50 micrograms, Mylan Pharmaceutical Company, Saint Priest, France) has been used for intubation.