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IRCT2012100611023N1 IRCT 2013-04-24 Tehran University of Medical Sciences Factors affecting the outcome of Lumbosacral Spinal Surgery Evaluating the effect of Acetazolamide adminestration and prone positioning following lumbosacral spinal surgery in preventing cerebro spinal fluid leak and collection and wound dehissence 2012-09-22 anticipated 144 Complete https://irct.ir/trial/11392 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Factorial, Purpose: Prevention. 3 Condition 1: Tethered cord- split cord malformation. Condition 2: Lipomyelomeningocele. Intervention 1: Group A: Acetazolamide administration (as tablet or solved in water, dosage depending on the weight of the child) for 10 days. Intervention 2: Group C: Acetazolamide administration(as tablet or solved in water, dosage depending on the weight of the child) for 10 days+ prone positioning for 10 days. Intervention 3: Group B: prone positioning for 10 days. Intervention 4: Group D: no intervention.
public Shima Shahjouei
Iran, Tehran, Poursina st., Keshavarz blv., Tehran University of Medical Sciences
Tehran Iran (Islamic Republic of) +98 21 8825 6697 shimashah@student.tums.ac.ir Tehran University of Medical Sciences scientific Farideh Nejat
Poursina st., Keshavarz blv.
Tehran Iran (Islamic Republic of) +98 66420098 nejat@tums.ac.ir Tehran University of Medical Sciences Iran (Islamic Republic of) The patients visiting the neurosurgery clinic of children`s medical center hospital during Autumn 2012 to the end of winter of 2015 who need lumbosacral surgery will be screened. If these patients underwent unthetering surgery due to primary tethered cord syndrome, resection of lipoma, lipomyelomeningocele, split cord malformation management, tumors with intradural management or having any other disease with similar management technique due to the opinion of the surgeon, they will be included. Patients with diagnosis of myelomeningocele, meningocele, infected dermoid cysts, intramedullary abscess, presence of hydrocephalus and those who underwernt reoperation will be excluded from this study. no limit 18 years Both G93.9 D17.9 Disorder of brain, unspecified Benign lipomatous neoplasm, unspecified Prevention Prevention Prevention N/A Group A: Acetazolamide administration (as tablet or solved in water, dosage depending on the weight of the child) for 10 days Group C: Acetazolamide administration(as tablet or solved in water, dosage depending on the weight of the child) for 10 days+ prone positioning for 10 days Group B: prone positioning for 10 days Group D: no intervention Cerebrospinal fluid leakage. Timepoint: 1month. Method of measurement: specialist opinion. Cerebrospinal fluid collection. Timepoint: 1 month. Method of measurement: specialist opinion. Wound dehiscence. Timepoint: 1 month. Method of measurement: specialist opinion. Tehran University of Medical Sciences Approved 2012-12-04 Medical ethics and history of medicine research center of Tehran University of Medical Sciences 4th Floor, No. 23, before Pour Sina St. - 16th Azad St. - Keshavarz Blvd. Tehran Iran (Islamic Republic of)