IRCT2012100611013N1 IRCT 2017-08-26 Mazandaran University of Medical Sciences Comparison of the effect of N-acetylcysteine plus carvedilol, with carvedilol alone, in the prevention of atrial fibrillation after open heart surgery Comparison of the effect of N-acetylcysteine plus carvedilol, with carvedilol alone, in the prevention of atrial fibrillation after open heart surgery 2015-09-23 anticipated 300 Complete https://irct.ir/trial/11375 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. N/A Atrial Fibrillation. Intervention 1: Case group:All of patients who are candidated for open heart surgery and didn't have contraindication for Beta blocker underwent premedication with oral carvedilol with doses 6.25 mg twice days for 3 days before open heart surgery, In these patients, at the time of initiation of cardiopulmonary bypass and when using a cardiopulmonary solution for cardiac arrest, n-acetylcysteine at a rate of 4 milimole per liter (50 mg / kg) was added to the second cardioplegic solution in a single dose, and Eventually, the solution is used during the operation on the heart tissue.and they are monitored for five days in the intensive care unit. Intervention 2: Control group:All of patients who are candidated for open heart surgery and didn't have contraindication for Beta blocker underwent premedication with oral carvedilol with doses 6.25 mg twice days for 3 days before open heart surgery For this patients,after initiation of cardiopulmonary bypass,equal volume of normal salin solution added to cardioplegic solution and The obtained solution was used without any extra material on the heart tissue during surgery.and they are monitored for five days in the intensive care unit.