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IRCT2016011810782N2 IRCT 2016-05-28 Tehran University of Medical Sciences Effectiveness of cognitive remediation in schizophrenia Effectiveness of a computerized cognitive remediation program on cognitive functioning of patients with schizophrenic disorders: A randomized controlled study 2016-02-04 anticipated 62 Complete https://irct.ir/trial/11201 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Other. 3 Condition 1: Schizoaffective Disorder. Condition 2: Schizophrenia. Intervention 1: Computer assisted cognitive remediation that consists of 10 training sessions using tasks in Cogpack software for improvement of memory, attention and executive functions. Sessions are delivered in 2-3 per week frequency. Intervention 2: Treatment-as-usual that usually consists of antipsychotic medications in standard maintenance dosage prescribed by a physician and accompanied by patient education.
public Azadeh Sedighnia
South Kargar Avenue
Tehran Iran (Islamic Republic of) +98 21 5541 9151 Azadehsedighnia@yahoo.com Roozbeh Hospital scientific Vandad Sharifi
South Kargar Avenue
Tehran Iran (Islamic Republic of) +98 21 5541 9151 Vsharifi@sina.tums.ac.ir Roozbeh Hospital Iran (Islamic Republic of) Inclusion criteria: Patients with DSM-IV schizophrenia or schizoaffective disorder, aged 18 to 55 years and with education not less than 3rd grade in guidance school. Patients will be clinically stable and not acutely psychotic (Clinical Global Impression scale score less than 4, and Positive and Negative Syndrome Scale score less than 50). The dosage and the type of antipsychotic medications patients will receive at least during the three weeks prior to the study will be unchanged. At least 12 hours before the intervention, patients will receive their last dose of a benzodiazepine (if any) but no antihistamine medication will be administered. Exclusion criteria: Receiving electroconvulsive therapy (ECT) within six weeks prior to the study, mental retardation, uncorrected visual impairment, concurrent consumption of substances with the exception of nicotine and caffeine, a history of head trauma followed by loss of consciousness, suffering from a major neurological disorder (including epilepsy, Parkinson’s disease, dementia, multiple sclerosis, or any motor disability), severe worsening of illness during study requiring a change in medical treatments. 18 years 55 years Both F25 F20 Schizoaffective disorder Schizophrenia Rehabilitation Treatment - Other Computer assisted cognitive remediation that consists of 10 training sessions using tasks in Cogpack software for improvement of memory, attention and executive functions. Sessions are delivered in 2-3 per week frequency. Treatment-as-usual that usually consists of antipsychotic medications in standard maintenance dosage prescribed by a physician and accompanied by patient education. Executive function. Timepoint: Before and after the intervention. Method of measurement: CANTAB Battery. Attention. Timepoint: Before and after the intervention. Method of measurement: CANTAB Battery. Memory. Timepoint: Before and after the intervention. Method of measurement: CANTAB Battery. Global Function. Timepoint: Before and after the intervention. Method of measurement: Global Assessment of Functioning. Quality of life. Timepoint: Before and after the intervention. Method of measurement: Quality of life questionnaire. Severity of illness. Timepoint: Before and after the intervention. Method of measurement: Positive and Negative Syndrome Scale, and Clinical global impression. Tehran University of Medical Sciences Approved 2016-02-08 Ethics Committee of Tehran University of Medical Sciences Ghods Avenue, Keshavarz Boulevard Tehran Iran (Islamic Republic of)