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IRCT2012082510657N1 IRCT 2012-11-26 Vice chancellor for research; Shiraz University of Medical Sciences Effectiveness of uterine local injury in improving pregnancy in unexplained infertility To compare the effect of endometrial local injury on frequency of pregnancy in couples with unexplained infertility by control group 2010-01-01 anticipated 234 Complete https://irct.ir/trial/11098 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Infertility. Intervention 1: All the patients will undergo optimal superovulation by clomiphene-citrate (Razac Drug Laboratory,Tehran,Iran ) orally administered 100 milligram/day from day 3 to day 7 of the cycle and HMG-Merional (IBSA , Lugarno , Switzerland) intramuscularly administered 75 International Unit/day from the 6th to the 8th day. just in the case group mild endometrial local injury was performed in the posterior fundal wall of the uterus by standard piplle endometrial sampling (Pipelle de Cornier, Prodimed, Neuilly-en-Thelle, France) during the preovulatory days (the day of detecting urinary lutenizing hormone (LH)-surge) . Then all the patients in both groups were instructed to follow a regularly timed intercourse. Intervention 2: In the control group no intervention will be done.
public Najmeh Maharlouei
Building No. 2, 8th Floor, Medical School, Zand Avenue, Shiraz, Iran Tel/Fax: +98-711-2309615
Shiraz Iran (Islamic Republic of) +98 71 1230 2799 najmeh.maharlouei@gmail.com Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran scientific Nasrin Dadras
Infertility Research Center, 4th Floor, Ghadir Hospital, Ghoran Avenue
Shiraz Iran (Islamic Republic of) +98 71 1646 2610 dadras.nasrin@gmail.com Infertility Research Center Iran (Islamic Republic of) Inclusion criteria: 1) Couples with no obvious reasons for infertility(normal routine infertility evaluation evaluation of infertility are normal) referring to Infertility Research Center in Shiraz, Iran were included in this study. 2) infertile women who were in their 23-35 years of age, 3) body mass index between 18 and 25 (kg/m2), 4)anti-mullerian hormone more than 1 µg/l ,5) follicle stimulating hormone levels less than 10 mIU/ml on the third day of cycle, 6) at least 10-12 follicles in AFC count and 7) couples receiving no drugs for infertility at least for three previous months . The exclusion criteria were 1) women younger than 23 or older than 35, as well as those (each of the infertile partner) who were cigarette smoker, and/or alcohol abuser. 23 years 35 years Female N97.9 Female infertility, unspecified Treatment - Other Treatment - Drugs All the patients will undergo optimal superovulation by clomiphene-citrate (Razac Drug Laboratory,Tehran,Iran ) orally administered 100 milligram/day from day 3 to day 7 of the cycle and HMG-Merional (IBSA , Lugarno , Switzerland) intramuscularly administered 75 International Unit/day from the 6th to the 8th day. just in the case group mild endometrial local injury was performed in the posterior fundal wall of the uterus by standard piplle endometrial sampling (Pipelle de Cornier, Prodimed, Neuilly-en-Thelle, France) during the preovulatory days (the day of detecting urinary lutenizing hormone (LH)-surge) . Then all the patients in both groups were instructed to follow a regularly timed intercourse. In the control group no intervention will be done. Pregnancy. Timepoint: two weeks after the missed period. Method of measurement: measuring level of blood Beta human chorionic gonadotropin by ELISA. Clinical pregnancy. Timepoint: 4 weeks after the missed period. Method of measurement: detecting of intrauterine sac by vaginal sonography. Vice chancellor for research; Shiraz University of Medical Sciences Approved 2012-10-02 Ethics committee of Shiraz University of Medical Sciences 8th Floor, main building of Shiraz University of Medical Sciences, Zand Avenue Shiraz Iran (Islamic Republic of)