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IRCT2016100710599N13 IRCT 2016-11-18 Vice chancellor of Research- Iran University of Medical Sciences New therapeutic methods for drug induced early menopause in breast cancer patients instead of hormone replacement therapy Comparison of the effect of stellate ganglion block and paroxetine on hot flashes and sleep disturbances in breast cancer survivors 2016-10-06 anticipated 36 Complete https://irct.ir/trial/11067 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 1 drug induced early menopause in breast cancer. Intervention 1: Advising of oral paroxetine 7.5 mg daily for 6 weeks in control group. Intervention 2: Stellate ganglion block under sonographic guidance with 10 ml of 0.5% bupivacaine in study group.

public Behzad Ebrahimi MD

Hazrat-e Rasool Hospital - Pain operating room

Tehran Iran (Islamic Republic of) +98 21 6435 2107 behzade49@yahoo.com Iran University of Medical Sciences scientific Poupak Rahimzade MD

Hazrat-e Rassol Hospital

Tehran Iran (Islamic Republic of) +98 21 6435 2107 poupak_rah@hotmail.com Iran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: symptoms suffering for a minimum period of one month, age 21 to 45 y/o, and life expectancy greater than 6 month. Exclusion criteria: patients under treatment with chemotherapy drugs, androgens, estrogens, progesterone analogs, or other known treatments of menopausal symptoms for example vitamin E, antidepressants and gabapentin, coagulation abnormalities, aspirin users, acute infections, cardiac diseases and ASA class ≥3. 21 years 45 years Female N95 - 3 Post-artificial-menopause syndrome Treatment - Drugs Treatment - Other Advising of oral paroxetine 7.5 mg daily for 6 weeks in control group Stellate ganglion block under sonographic guidance with 10 ml of 0.5% bupivacaine in study group Hot flashes. Timepoint: before intervention and 2, 4 and 6 weeks after interventin. Method of measurement: Sloan and coworkers raing scale. Sleep quality. Timepoint: before intervention and 2, 4 and 6 weeks after interventin. Method of measurement: The Pittsburgh Sleep Quality Index (PSQI). Vice chancellor of Research- Iran University of Medical Sciences Approved 2016-09-18 Ethics committee of Iran University of Medical Sciences Tehran - Shahid Hemmat Highway Tehran Iran (Islamic Republic of)