IRCT2012091210508N4 IRCT 2012-10-20 Shahid Beheshti University of Medical Science Effect of Zonisamide and Pregabalin in control of interactable epilepsy in children Comparisson of the effect of Zonisamide and Pregabalin as adjunctive therapy in control of interactable epilepsy in children 2012-04-01 anticipated 96 Complete https://irct.ir/trial/11012 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Interactable epilepsy. Intervention 1: Ninety six children with seizures which admitted to Mofid children hospital and despite taking two or three anti-seizure medication, have uncontrolled seizure and have no neurodegenerative diseases has been randomly divided into two groups (1 and 2) and the group 1 will be treated with Zonisamaide oraly with dose of 2 - 12 miligram per kilogram daily and after one month and six months since drugs starting reduction of the frequency and severity of seizures are analyzed and compared with group 2. During the follow-up over fifty percent reduction in seizure frequency or severity is known as a response to drug . Intervention 2: Ninety six children with seizures which admitted to Mofid children hospital and despite taking two or three anti-seizure medication, have uncontrolled seizure and have no neurodegenerative diseases has been randomly divided into two groups (1 and 2) and the group 2 will be treated with Pregabalin oraly with dose of 5-15 miligram per kilogram daily and after one month and six months since drugs starting reduction of the frequency and severity of seizures are analyzed and compared with group 1. During the follow-up over fifty percent reduction in seizure frequency or severity is known as a response to drug .