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IRCT2012071910328N2 IRCT 2012-11-14 Wise Canceler of Shahid Sadoughi University of Medical Sciences of Yazd,Research and Clinical Cente Comparison of two protocol of endometrial preparation in thawed- embryo transfer cycles Comparison of effect of transdermal estradiol and estradiol valerate on endometrial receptivity in frozen-thawed embryo transfer cycles 2012-04-01 anticipated 90 Complete https://irct.ir/trial/10838 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Infertility. Intervention 1: In intervention group (45 patients),at the same time of menses will applied 17-B estradiol transdermal patches 100 mcg every other day that each patch will removed after four days .In both group clinical monitoring by transvaginal ultrasound will done on 11th day of menstruation to measure endometrial thickness. While endometrial thickness is less than 7.5 mm, will increased dose of17-B estradiol transdermal patches to 200 mcg daily .After 3 day will repeated monitoring and while endometrial thickness are more than or equal 7.5 , 100 mg progesterone in oil daily IM injection will be done. After 48-72 hours, between 1-3 embryo will transferred trans-cervically. Hormonal therapy will continued till pregnancy test after 2 weeks. While pregnancy test is positive , 2-3 weeks after, sonography for observation of the fetal heart activity will done. If pregnancy document with sonography , hormonal therapy continue till 10th weeks of pregnancy. Intervention 2: In control group (45 patients), for endometrial preparation will started from 2nd day of cycle oral estradiol 6 mg daily. In both group clinical monitoring by transvaginal ultrasound will done on 11th day of menstruation to measure endometrial thickness. While endometrial thickness is less than 7.5 mm, will increased dose of oral estradiol to 2mg each 6 hours .After 3 day will repeated monitoring and while endometrial thickness are more than or equal 7.5 , 100 mg progesterone in oil daily IM injection will be done. After 48-72 hours, between 1-3 embryo will transferred trans-cervically. Hormonal therapy will continued till pregnancy test after 2 weeks. While pregnancy test is positive , 2-3 weeks after, sonography for observation of the fetal heart activity will done. If pregnancy document with sonography , hormonal therapy continue till 10th weeks of pregnancy.
public Dr.Sima Janati
Bouali Ave, Safayeh، Research and Clinical Center for Infertility, Yazd
Yazd Iran (Islamic Republic of) +98 35 1824 7085 janati@dums.ac.ir Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences Yazd scientific Dr.Robab Davar
Bouali Ave, Safayeh , Research and Clinical Center for Infertility, Yazd
Yazd Iran (Islamic Republic of) +98 35 1824 7085 r-davar@yahoo.com Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences,Yazd Iran (Islamic Republic of) Inclusion criteria: female Exclusion criteria: FSH in day 3 of cycle more than 12 ; age below 20 and more than 40 years; bad qaulity vitrified/warmed embryo; polycystic ovarian syndrome ; endocrine or metabolic disorder;endometriosis ; egg donation 20 years 40 years Female N98.9 Complication associated with artificial fertilization, unspecified Treatment - Drugs Treatment - Drugs In intervention group (45 patients),at the same time of menses will applied 17-B estradiol transdermal patches 100 mcg every other day that each patch will removed after four days .In both group clinical monitoring by transvaginal ultrasound will done on 11th day of menstruation to measure endometrial thickness. While endometrial thickness is less than 7.5 mm, will increased dose of17-B estradiol transdermal patches to 200 mcg daily .After 3 day will repeated monitoring and while endometrial thickness are more than or equal 7.5 , 100 mg progesterone in oil daily IM injection will be done. After 48-72 hours, between 1-3 embryo will transferred trans-cervically. Hormonal therapy will continued till pregnancy test after 2 weeks. While pregnancy test is positive , 2-3 weeks after, sonography for observation of the fetal heart activity will done. If pregnancy document with sonography , hormonal therapy continue till 10th weeks of pregnancy. In control group (45 patients), for endometrial preparation will started from 2nd day of cycle oral estradiol 6 mg daily. In both group clinical monitoring by transvaginal ultrasound will done on 11th day of menstruation to measure endometrial thickness. While endometrial thickness is less than 7.5 mm, will increased dose of oral estradiol to 2mg each 6 hours .After 3 day will repeated monitoring and while endometrial thickness are more than or equal 7.5 , 100 mg progesterone in oil daily IM injection will be done. After 48-72 hours, between 1-3 embryo will transferred trans-cervically. Hormonal therapy will continued till pregnancy test after 2 weeks. While pregnancy test is positive , 2-3 weeks after, sonography for observation of the fetal heart activity will done. If pregnancy document with sonography , hormonal therapy continue till 10th weeks of pregnancy. Endometrial thickness. Timepoint: 10-20 days. Method of measurement: Measurement between two layers of endometrium by vaginal sonography. Clinical pregnancy. Timepoint: 4-5 weeks after embryo transfer. Method of measurement: Observation of fetal heart activity by transvaginal sonography. Time of endometrial preparation. Timepoint: 11-14 days. Method of measurement: Repeated vaginal sonography. Cancelation rate of cycles. Timepoint: 10-20 days. Method of measurement: Repeated vaginal sonography. Chemical pregnancy. Timepoint: Two weeks after embryo transfer. Method of measurement: BHCG test. Wise Canceler of Shahid Sadoughi University of Medical Sciences of Yazd,Research and Clinical Cente Approved 2012-03-15 Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences,Yazd,Ir Bouali Ave, Safayeh, Research and Clinical Center for Infertility, Yazd Yazd Iran (Islamic Republic of)