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IRCT2012072310311N2 IRCT 2013-09-09 Shiraz University of Medical Sciences Atorvastatin in open heart surgery Comparition of effect of high dose and low dose atorvastatin treatment on outcome of patients underwent CABG 2013-08-23 anticipated 100 Complete https://irct.ir/trial/10764 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. N/A Condition 1: Coronary artery bypass graft. Condition 2: Diabet melitus. Condition 3: Atrial fibrilation. Condition 4: Deliriom. Condition 5: Acute myocardial ischemia and infarction. Intervention 1: Patients in this study werw generally used 10 to 20 mg atorvastatin daily. Patients in this group, recived Atorvastatin 80 mg daily for 3 days before surgery and received postoperative low dose of 20 mg daily during the ICU stay. Intervention 2: The control group received 20 mg atorvastatin daily and continues in ICU.
public Misagh Bastani
Department of Anesthesiology-Operating room. namazi hospital
Shiraz Iran (Islamic Republic of) 7194714487 +98 71 1647 4270 bastanim@sums.ac.ir; misaghbastani@ymail.com Shiraz University of Medical Sciences scientific Mohamad Bagher Khosravi
Hengam Street. Lane 6/2. Last door on the right. Nyaysh Boulevard.Shiraz.
Shiraz Iran (Islamic Republic of) +98 71 1654 1174 khosravimb@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: patients admitted in Nemazee hospital who underwent CABG on CPB; after learning of the investigation and completed an informed consent, were randomized to receive atorvastatin are divided into two groups. Exclusion criteria: unstable angina; myocardial infarction; evidence of recent MI (within 6 months); history of previous cardiac surgery; emergency surgery; congenital heart disease; a history of cardiac arrhythmias (Atrial Fibrilation) preoperatively received antiarrhythmic drugs (except Beta blocker); having Pacemaker; Left Ventricle Edjection Fraction less than 30%; uncontrolled hypertension; persistant atrial or ventricular arrhythmia; pregnant women; a history of diabet under treatment; elevated liver enzymes; renal failure with creatinine greater than 2mg/dl; inflammation or immune activation; muscle disease and alergy to statins. no limit no limit Both T82-2 E10-11 I48 F05 I21 Mechanical complication of coronary artery bypass and valve grafts Insulin-dependent diabetes mellitus-Non-insulin-dependent diabetes mellitus Atrial fibrillation and flutter Delirium, not induced by alcohol and other psychoactive substances Acute myocardial infarction Treatment - Drugs Treatment - Drugs Patients in this study werw generally used 10 to 20 mg atorvastatin daily. Patients in this group, recived Atorvastatin 80 mg daily for 3 days before surgery and received postoperative low dose of 20 mg daily during the ICU stay The control group received 20 mg atorvastatin daily and continues in ICU CK-MB. Timepoint: Befor induction, 24 and 48 h after surgery. Method of measurement: Labratory kit. CRP. Timepoint: Befor induction, 24 and 48 h after surgery. Method of measurement: Laberatory kit. Blood suger. Timepoint: Before induction, in pump, after off pump, every 6h upto48 h, then daily. Method of measurement: Glucometr. Atrial fibrilation. Timepoint: During operation, in course of ICU admission. Method of measurement: Continioues ECG monitoring. MACE(magor adverse cardiac events). Timepoint: In ICU and up to 1 month after surgery. Method of measurement: Echocardiography. Ceratinin. Timepoint: Before surgery, daily up to 3 days. Method of measurement: Laberatory kit. Hematocrit. Timepoint: Before surgery,in pump,off-pump,days of 1&2&3. Method of measurement: Laberatoty kit. Liver function tests. Timepoint: Befor surgery,second day after operation. Method of measurement: Lab kit. Delirium. Timepoint: In course of ICU admission. Method of measurement: Richmond scale daily. Shiraz University of Medical Sciences Approved 2013-08-04 Shiraz University of Medical Sciences the central building of shiraz University-zand street shiraz Iran (Islamic Republic of)