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IRCT2016102510210N6 IRCT 2016-10-30 Shiraz University Of Medical Science effect of platelet-rich plasma(PRP)on fertility in women with thin endometrium effect of intrauterine infusion of autologous platelet-rich plasma(PRP)on endometrial thickness and pregnancy rate as secondary endpoint in FET cycles. 2016-09-22 anticipated 100 Complete https://irct.ir/trial/10685 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A noninflammatory disorder of female genital tract. Intervention 1: Control group: Continue estradiol since day 2 of cycle till end of study. Intervention 2: - Intrauterine infusion of 0.5 cc of platelet rich plasma( PRP)that contained platelet 4-5 times more than peripheral blood with uterine catheter is performed if endometrial thickness below 6 mm on day 10 of cycle and the procedure is repeated 72 hours later if the endometrial thickness below 6mm.
public Mohadese Shirbani
Shiraz University of Medical Sciences ، Zand Street
Shiraz Iran (Islamic Republic of) +98 71 3227 9715 shirbanim@gmail.com Shiraz University Of Medical Science scientific Afsoon Zarei
Shiraz University of Medical Science , Zand Street
Shiraz Iran (Islamic Republic of) +98 71 3227 9715 zareia@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) All patient with infertility that refer to mother and child hospital due to embryo transfer and recently despite conventional treatment with low dose of estradiol(6 mg)in 10th day cycles have endometrial thickness less than 6 mm no have above factors or no agree of patients platelet dysfunction ,thrombocytopenia ,continue using NSAIDs in the recent 48 hours ,corticosteroids in the 1 mount before ,smoking ,recent fever, history of cancer ,Hb<,platelet<105000 20 years 45 years Female N98.9 Complication associated with artificial fertilization ,unspecified Treatment - Drugs Treatment - Drugs Control group: Continue estradiol since day 2 of cycle till end of study - Intrauterine infusion of 0.5 cc of platelet rich plasma( PRP)that contained platelet 4-5 times more than peripheral blood with uterine catheter is performed if endometrial thickness below 6 mm on day 10 of cycle and the procedure is repeated 72 hours later if the endometrial thickness below 6mm Endometrial thickness. Timepoint: in 10th day of cycles and 72 hr after infusion of PRP. Method of measurement: Trans vaginal sonography. Clinical pregnancy or miscarriage. Timepoint: 4week after embryo transfer. Method of measurement: trans vaginal sonography. Shiraz University Of Medical Science Approved 2016-04-10 Medical Science Researching، Shiraz Univercity of Medical Science Shiraz University of Medical Sciences، Zand Street، Shiraz Shiraz Iran (Islamic Republic of)