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IRCT2012100210181N2 IRCT 2013-11-27 Nutrition and Metabolic Diseases Reearch Center in Ahvaz Jundishapur University of Medical sciences Evaluation of the effect of Hesperidin supplementation in patients with myocardial infarction Evaluation of the effect of Hesperidin supplementation on the serum levels of inflammatory markers (E-selectin, Interlukin 6, hs-CRP) and Adipocytokines (leptin and adiponectin) in patients with myocardial infarction 2012-10-22 anticipated 60 Complete https://irct.ir/trial/10638 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Myocardian infarction. Intervention 1: For the subjects in the intervention group, one capsule included 600 mg pure hesperidin was provided to consume in the morning with breakfast every day for 4 weeks. Intervention 2: the control group received on placebo capsule that was similar the color and shape of hesperidin capsule but included 600 mg starch,in the breakfast for 4 weeks.
public Fatemeh Haidari
Paramedical school of Ahvaz Jundishapur University of Medical Sciences
Ahvaz Iran (Islamic Republic of) +98 61 1373 8383 haidari58@gmail.com Ahvaz Jundishapur University of Medical Sciences scientific Fatemeh Haidari
Paramedical school of Ahvaz Jundishapur University of Medical Sciences
Ahvaz Iran (Islamic Republic of) +98 61 1373 8383 haidari58@gmail.com Ahvaz Jundishapur University of Medical Sciences Iran (Islamic Republic of) The inclusion criteria were patients with myocardial infarction, being in the range of 40-65 years old, having body mass index (BMI) from 18.5-30 and patients satisfaction. Exclusion criteria included chronic disease (such as Hepatic disorders, Renal failure, diabetes, et.al.), Gastrointestinal disorders, major psychiatric disorder, taking antidepressants,absolute vegetarian diet, consumption of antioxidant and vitamin supplements at least 6 month before sampling,High consumption of flavonoid-rich beverages (including green tea, coffee, Juice, et.al.), smoking, allergies to any vitamin supplements, lack of patient follow-up and lack of consent. 40 years 65 years Both I21 Acute myocardial infarction Treatment - Drugs Treatment - Drugs For the subjects in the intervention group, one capsule included 600 mg pure hesperidin was provided to consume in the morning with breakfast every day for 4 weeks the control group received on placebo capsule that was similar the color and shape of hesperidin capsule but included 600 mg starch,in the breakfast for 4 weeks. IL-6. Timepoint: before intervention and after one month intervention. Method of measurement: plasma levels. Hs-CRP. Timepoint: before intervention and after one month intervention. Method of measurement: plasma levels. Leptin. Timepoint: before intervention and after one month intervention. Method of measurement: plasma levels. Adiponectin. Timepoint: before intervention and after one month intervention. Method of measurement: plasma levels. E-selectin. Timepoint: before intervention and after one month intervention. Method of measurement: plasma levels. Physical activity. Timepoint: before and end of intervention. Method of measurement: IPAQ questionaire. Anthropometric indices. Timepoint: before and end of intervention. Method of measurement: meter and scale balance. Dietary assessment. Timepoint: before, middle and end of intervention. Method of measurement: The three-day, 24-hour food recall. Nutrition and Metabolic Diseases Reearch Center in Ahvaz Jundishapur University of Medical sciences Approved 2010-08-20 Ahvaz Jundishapur University of Medical Sciences Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran (Islamic Republic of)